Fmoc-L-tert-leucine

Synonym(s):Fmoc-α-t-butylglycine;Fmoc-L-tert-leucine;Fmoc-Tle-OH;N-α-Fmoc-L-α-t.-butyl-glycine, Fmoc-Tle-OH

CAS NO.：132684-60-7
Empirical Formula: C21H23NO4
Molecular Weight: 353.41
MDL number: MFCD00065649
SAFETY DATA SHEET (SDS)
Update Date: 2023-11-29 17:10:20

What is Fmoc-L-tert-leucine?

Chemical properties

solid

The Uses of Fmoc-L-tert-leucine

Fmoc-Tle-OH is a versatile reactant used in the discovery of potent antagonists of antiapoptotic protein X-linked inhibitor of apoptosis (XIAP) for treatment of cancer. It is also used as reactant in the preparation of phosphino dipeptide derivatices as ligand in copper-phosphine catalyst for asymmetric conjugate addition of alkylzinc reagents to unsaturated ketones.

What are the applications of Application

Fmoc-tBu-Gly-OH is an Fmoc protected glycine derivative

Properties of Fmoc-L-tert-leucine

Melting point:	124-127 °C
Boiling point:	554.1±33.0 °C(Predicted)
Density	1.209±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	≥ 35.3mg/mL in DMSO, ≥ 49.6 mg/mL in EtOH
pka	3.92±0.10(Predicted)
form	powder to crystal
color	White to Light yellow
BRN	6662856
CAS DataBase Reference	132684-60-7(CAS DataBase Reference)

Safety information for Fmoc-L-tert-leucine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.