FMoc-N-Me-Cys(Trt)-OH
Synonym(s):Fmoc-N-Me-Cys(Trt)-OH;N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine
- CAS NO.:944797-51-7
- Empirical Formula: C38H33NO4S
- Molecular Weight: 599.74
- MDL number: MFCD11973909
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:11
What is FMoc-N-Me-Cys(Trt)-OH?
The Uses of FMoc-N-Me-Cys(Trt)-OH
Fmoc-N-Me-L-Cys(Trt)-OH (CAS# 944797-51-7) is an fmoc- and trityl-protected derivative of L-cysteine (C995000) used as a building block for peptides or peptide fragments, such as the solid-phase synthesis of Triostin A.
The Uses of FMoc-N-Me-Cys(Trt)-OH
Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine).
It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A.
Properties of FMoc-N-Me-Cys(Trt)-OH
Melting point: | 234-239°C |
Boiling point: | 746.0±60.0 °C(Predicted) |
Density | 1.260±0.06 g/cm3(Predicted) |
storage temp. | Store at -15°C to -25°C. |
form | Solid |
pka | 3.72±0.10(Predicted) |
color | White to off-white |
optical activity | [α]22/D -25.0°, c = 0.5% in dichloromethane |
Safety information for FMoc-N-Me-Cys(Trt)-OH
Computed Descriptors for FMoc-N-Me-Cys(Trt)-OH
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