Fluphenazine decanoate
- CAS NO.:5002-47-1
- Empirical Formula: C32H44F3N3O2S
- Molecular Weight: 591.77
- MDL number: MFCD00798504
- EINECS: 225-672-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is Fluphenazine decanoate ?
Chemical properties
Yellow Oil
The Uses of Fluphenazine decanoate
Fluphenazine Decanoate is used in psychotropic drug treatments like those relating to schizophrenia. Antipsychotic.
Definition
ChEBI: Fluphenazine decanoate is the prodrug of fluphenazine, an antipsychotic drug used for the symptomatic management of psychosis in patients with schizophrenia. It has a role as a phenothiazine antipsychotic drug, a prodrug and a dopaminergic antagonist. It is a member of phenothiazines, a decanoate ester, an organofluorine compound and a N-alkylpiperazine. It is functionally related to a fluphenazine.
Clinical Use
AntipsychoticSchizophrenia and other psychoses
Drug interactions
Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedative effects with opioids. Anti-arrhythmics: increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval; increased risk of ventricular arrhythmias with amiodarone and dronedarone - avoid; increased risk of ventricular arrhythmias with disopyramide.Antibacterials: increased risk of ventricular arrhythmias with delamanid and moxifloxacin - avoid Antidepressants: increased risk of ventricular arrhythmias with tricyclics, citalopram, escitalopram; possible increased risk of convulsions with vortioxetineAntiepileptics: antagonises anticonvulsant effect.Antimalarials: increased risk of ventricular arrhythmias with artenimol with piperaquine and artemether/lumefantrine - avoid.Antipsychotics: increased risk of ventricular arrhythmias with droperidol, pimozide and risperidone - avoid; avoid use of depot formulations with clozapine (cannot be withdrawn quickly if neutropenia occurs).Antivirals: increased risk of ventricular arrhythmias with saquinavir - avoid; concentration possibly increased with ritonavir.Anxiolytics and hypnotics: increased sedative effectsAtomoxetine: increased risk of ventricular arrhythmias.Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalolCytotoxics: increased risk of ventricular arrhythmias with arsenic trioxideDiuretics: enhanced hypotensive effect.Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity.Pentamidine: increased risk of ventricular arrhythmias - avoid.Avoid with drugs that prolong the QT interval.
Metabolism
The cytochrome P450 isoenzyme CYP2D6 is involved in fluphenazine metabolism.
Properties of Fluphenazine decanoate
Melting point: | 30-32° |
Boiling point: | 658.1±55.0 °C(Predicted) |
Density | 1.149±0.06 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | Practically insoluble in water, very soluble in ethanol and in methylene chloride, freely soluble in methanol. |
form | neat |
pka | 7.32±0.10(Predicted) |
form | Oil |
color | Light yellow to yellow |
CAS DataBase Reference | 5002-47-1 |
Safety information for Fluphenazine decanoate
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H300:Acute toxicity,oral H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for Fluphenazine decanoate
Abamectin manufacturer
Ralington Pharma
Gland Pharma Ltd
Flowchem Pharma Pvt Ltd
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