FluoroMethyl 2-pyridyl sulfone
- CAS NO.：1365765-53-2
- Empirical Formula: C6H6FNO2S
- Molecular Weight: 175.18
- MDL number: MFCD28100935
- Update Date: 2024-01-22 13:44:12
What is FluoroMethyl 2-pyridyl sulfone?
Description
Fluoromethyl 2-pyridyl sulfone and its derivatives can be used as novel monofluoromethylation reagents. The monofluorinated sulfinate intermediates during the monofluoroolefination of aldehydes and ketones can be halogenated in situ to afford mono- and dihalofluoroalkyl compounds. The coupling reaction between iodofluoromethyl 2-pyridyl sulfone and aryl iodides mediated by copper can be used to prepare monofluoromethyl arenes and heteroarenes.
Chemical properties
white solid
Reactions
(1) Dihalofluoromethylation of aldehydes and ketones.
(2) Halofluoroalkylation of aldehydes.
(3) Monofluoromethylation of arenes and heteroarenes.
References
[1] YANCHUAN ZHAO Jinbo H Bing Gao. From Olefination to Alkylation: In-Situ Halogenation of Julia–Kocienski Intermediates Leading to Formal Nucleophilic Iodo- and Bromodifluoromethylation of Carbonyl Compounds[J]. Journal of the American Chemical Society, 2012, 134 13: 5790-5793. DOI:10.1021/ja301601b.
[2] YANCHUAN ZHAO. Copper-Mediated Fluoroalkylation of Aryl Iodides Enables Facile Access to Diverse Fluorinated Compounds: The Important Role of the (2-Pyridyl)sulfonyl Group[J]. Organic Letters, 2012, 14 23: 6080-6083. DOI:10.1021/ol3029737.
Properties of FluoroMethyl 2-pyridyl sulfone
| Boiling point: | 353.2±35.0 °C(Predicted) |
| Density | 1.348±0.06 g/cm3(Predicted) |
| pka | -3.04±0.19(Predicted) |
Safety information for FluoroMethyl 2-pyridyl sulfone
Computed Descriptors for FluoroMethyl 2-pyridyl sulfone
New Products
4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION Methylcobalamin (vitamin B12) SODIUM METHYL PARABEN SODIUM VALPROATE AMOXICILLIN (AMOXYCILLIN) TRIHYDRATE ACICLOVIRRelated products of tetrahydrofuran
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