Flumexadol

CAS NO.：30914-89-7
Empirical Formula: C11H12F3NO
Molecular Weight: 231.21
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:09

What is Flumexadol?

Biological Activity

Flumexadol is an orally active non-narcotic analgesic. It is a selective and affinity agonist of the 5-HT2C receptor with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, 40-fold more selective than the 5-HT2A receptor.

in vivo

In rats and dogs dosed with ¹⁴ C-Flumexadol (CERM1841), the ¹⁴ C is excreted in the urine. The ^{14 C eliminated in the faeces of dog is significantly higher than for rat. Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species. Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances. The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid. In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate. The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.}

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Properties of Flumexadol

Boiling point:	132 °C(Press: 10 Torr)
Density	1.2081 (estimate)
storage temp.	Store at -20°C
solubility	DMSO: 100 mg/mL (432.51 mM)
pka	8.41±0.40(Predicted)
form	Liquid
color	Colorless to light yellow