Fleroxacin
Synonym(s):6,8-Difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid;Megalocin;Megalone;
- CAS NO.:79660-72-3
- Empirical Formula: C17H18F3N3O3
- Molecular Weight: 369.34
- MDL number: MFCD00864880
- EINECS: 677-525-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is Fleroxacin?
Description
Fleroxacin is a new, once daily trifluoroquinolone antibacterial structurally related to norfloxacin. Available in both oral and IV formulations, it is reportedly useful in the treatment of gonorrhea, bacterial enteritis, chronic bronchitis and urinary tract infections. Fleroxacin has a longer serum half-life (9-12 hours) than other drugs of this class, such as ciprofloxacin, enoxacin and norfloxacin.
Chemical properties
White Needle-Like Crystals
Originator
Kyorin (Japan)
The Uses of Fleroxacin
An antibacterial
The Uses of Fleroxacin
antibiotic
The Uses of Fleroxacin
An antibacterial.
What are the applications of Application
Fleroxacin is an antiproliferative antibacterial agent
Definition
ChEBI: A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-n gative bacteria.
Manufacturing Process
6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-
oxoquinoline-3-carboxylic acid hydrochloride:
A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was
added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3-
carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent
evaporated and cooled, the residue was adjusted to pH 1 with aqueous
hydrochloric acid. The cooled mixture was filtered off and the solid
recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-
(4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08
g), melting point 269-271°C (decomp.).
brand name
Quinodis
Therapeutic Function
Antibacterial
Properties of Fleroxacin
Melting point: | 264-266°C |
Boiling point: | 535.3±50.0 °C(Predicted) |
Density | 1.409±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | 0.1 M NaOH: soluble10mg/mL |
form | solid |
pka | -0.54±0.20(Predicted) |
color | white to off-white |
Merck | 14,4099 |
CAS DataBase Reference | 79660-72-3(CAS DataBase Reference) |
Safety information for Fleroxacin
Signal word | Warning |
Pictogram(s) |
Health Hazard GHS08 |
GHS Hazard Statements |
H371:Specific target organ toxicity, single exposure |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Fleroxacin
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