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HomeProduct name listFleroxacin

Fleroxacin

Synonym(s):6,8-Difluoro-1-(2-fluoroethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid;6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid;Megalocin;Megalone;

  • CAS NO.:79660-72-3
  • Empirical Formula: C17H18F3N3O3
  • Molecular Weight: 369.34
  • MDL number: MFCD00864880
  • EINECS: 677-525-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-20 11:41:24
Fleroxacin Structural

What is Fleroxacin?

Description

Fleroxacin is a new, once daily trifluoroquinolone antibacterial structurally related to norfloxacin. Available in both oral and IV formulations, it is reportedly useful in the treatment of gonorrhea, bacterial enteritis, chronic bronchitis and urinary tract infections. Fleroxacin has a longer serum half-life (9-12 hours) than other drugs of this class, such as ciprofloxacin, enoxacin and norfloxacin.

Chemical properties

White Needle-Like Crystals

Originator

Kyorin (Japan)

The Uses of Fleroxacin

An antibacterial

The Uses of Fleroxacin

antibiotic

The Uses of Fleroxacin

An antibacterial.

What are the applications of Application

Fleroxacin is an antiproliferative antibacterial agent

Definition

ChEBI: A fluoroquinolone antibiotic that is 4-oxo-1,4-dihydroquinoline which is substituted at positions 1, 3, 6, 7 and 8 by 2-fluoroethyl, carboxy, fluoro, 4-methylpiperazin-1-yl and fluoro groups, respectively. It is active against many Gram-positive and Gram-n gative bacteria.

Manufacturing Process

6,8-Difluoro-1-(2-fluoroethyl)-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxoquinoline-3-carboxylic acid hydrochloride:
A mixed solution of 1-methylpiperazine (0.34 g) and pyridine (3 ml) was added to 6,7,8-trifluoro-1-(2-fluoroethyl)-1,4-dihydro-4-oxoquinoline-3- carboxylic acid (0.12 g) and heated to reflux for 6 hours. After the solvent evaporated and cooled, the residue was adjusted to pH 1 with aqueous hydrochloric acid. The cooled mixture was filtered off and the solid recrystallized from water to give 6,8-difluoro-1-(2-fluoroethyl)-1,4-dihydro-7- (4-methyl-1-piperazinyl)-4-oxoquinoline-3-carboxylic acid hydrochloride (0.08 g), melting point 269-271°C (decomp.).

brand name

Quinodis

Therapeutic Function

Antibacterial

Properties of Fleroxacin

Melting point: 264-266°C
Boiling point: 535.3±50.0 °C(Predicted)
Density  1.409±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  0.1 M NaOH: soluble10mg/mL
form  solid
pka -0.54±0.20(Predicted)
color  white to off-white
Merck  14,4099
CAS DataBase Reference 79660-72-3(CAS DataBase Reference)

Safety information for Fleroxacin

Signal word Warning
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H371:Specific target organ toxicity, single exposure
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for Fleroxacin

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