1-Methylpiperazine
Synonym(s):1-Methylpiperazine;N-Methylpiperazine
- CAS NO.:109-01-3
- Empirical Formula: C5H12N2
- Molecular Weight: 100.16
- MDL number: MFCD00005966
- EINECS: 203-639-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-02-07 15:53:59
![1-Methylpiperazine Structural](https://img.chemicalbook.in/CAS/GIF/109-01-3.gif)
What is 1-Methylpiperazine?
Description
The cyclic diamine 1-methylpiperazine is a pale yellow oil with a boiling point of 286 oC. It can be synthesized in several ways, including treating 1,4-dimethylpiperazine with Raney nickel (Yuan, Q.-l., et al., 2013). In 1998,?M. A. Pericàs and coauthors?used it to prepare resin-anchored chiral catalysts.
But the best use of 1-methylpiperazine may be protecting people from mosquito bites. U. R. Bernier and co-workers at the USDA Agricultural Research Service showed that bacteria on human skin form 1-methylpiperazine and other small heterocycles that?prevent mosquitoes from recognizing that someone is present. The researchers recently applied for a patent covering this use for the active compounds.
?
Chemical properties
clear liquid
The Uses of 1-Methylpiperazine
1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP)
The Uses of 1-Methylpiperazine
1-Methylpiperazine is used in the preparation of 2-(4-methyl-1-piperazinylmethyl)acrylophenone. It is involved in the preparation of 1-(4-methoxy-phenyl)-4-methyl-piperazine by reacting with 1-chloro-4-methoxy-benzene. It acts as an intermediate in the synthesis of active pharmaceutical ingredients like ofloxacin, rifampicin, clozapine, sildenafil, trifluoperazine and zopiclone. Further, it is used as a mimic template in the preparation of molecularly imprinted microspheres. In addition to this, it is used in the generation of difunctional strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative.
What are the applications of Application
1-Methylpiperazine is a useful mimic template for the preparation of MIMs
Definition
ChEBI: 1-Methylpiperazine is a N-methylpiperazine.
Hazard
Moderate fire risk.
Flammability and Explosibility
Flammable
Safety Profile
Poison by intraperitoneal route. Moderately toxic by inhalation, ingestion, and skin contact. A severe skin and eye irritant. Flammable liquid when exposed to heat or flame; can react with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx.
Properties of 1-Methylpiperazine
Melting point: | -6 °C |
Boiling point: | 138 °C(lit.) |
Density | 0.903 g/mL at 25 °C(lit.) |
vapor density | 3.5 (vs air) |
vapor pressure | 12 hPa (20 °C) |
refractive index | n |
Flash point: | 108 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Soluble), Methanol (Soluble) |
form | Liquid |
pka | pK1:4.94(+2);pK2:9.09(+1) (25°C,μ=0.1) |
Specific Gravity | 0.903 |
color | Clear |
PH | 11-12 (50g/l, H2O, 20℃) |
explosive limit | 1.2-9.9%(V) |
Water Solubility | soluble |
Sensitive | Hygroscopic |
BRN | 102724 |
CAS DataBase Reference | 109-01-3(CAS DataBase Reference) |
NIST Chemistry Reference | Piperazine, 1-methyl-(109-01-3) |
EPA Substance Registry System | Piperazine, 1-methyl- (109-01-3) |
Safety information for 1-Methylpiperazine
Signal word | Danger |
Pictogram(s) |
![]() Flame Flammables GHS02 ![]() Corrosion Corrosives GHS05 ![]() Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H226:Flammable liquids H312:Acute toxicity,dermal H314:Skin corrosion/irritation H331:Acute toxicity,inhalation |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P370+P378:In case of fire: Use … for extinction. |
Computed Descriptors for 1-Methylpiperazine
InChIKey | PVOAHINGSUIXLS-UHFFFAOYSA-N |
1-Methylpiperazine manufacturer
AKASH PHARMA EXPORTS
ARRAKIS INDUSTRIES LLP
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