FK 888
Synonym(s):(4R)-4-Hydroxy-1-[(1-methyl-1H-indol-3-yl)carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide hydrate;FK888 hydrate;N2-[(4R)-4-hydroxyl-1-(1-methyl-1H-indol-3-yl)carbonyl-L-prolyl]-N-methyl-N-phenylmethyl-3-(2-naphthyl)-L-alaninamide hydrate
- CAS NO.:138449-07-7
- Empirical Formula: C36H36N4O4
- Molecular Weight: 588.7
- MDL number: MFCD00274042
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is FK 888?
The Uses of FK 888
FK 888 is a neurokinin NK1 receptor antagonist, which is active both in vivo and in vitro.
Definition
ChEBI: (2S,4R)-4-hydroxy-1-[(1-methyl-3-indolyl)-oxomethyl]-N-[(2S)-1-[methyl-(phenylmethyl)amino]-3-(2-naphthalenyl)-1-oxopropan-2-yl]-2-pyrrolidinecarboxamide is a peptide.
Biological Activity
Selective, high affinity tachykinin NK 1 receptor antagonist (K i = 0.69 nM) that displays 320-fold selectivity for human over rat NK 1 receptors. Inhibits substance P-induced contraction of isolated guinea pig trachea (IC 50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration.
storage
Store at -20°C
Properties of FK 888
Boiling point: | 901.9±65.0 °C(Predicted) |
Density | 1.26±0.1 g/cm3(Predicted) |
storage temp. | Store at -20°C |
solubility | DMSO: ≥13mg/mL |
form | powder |
pka | 13.01±0.40(Predicted) |
color | white to tan |
optical activity | [α]/D -135 to -145°, c = 1 in methanol |
Safety information for FK 888
Computed Descriptors for FK 888
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin G Tubulysin D Tubulysin B Tubulysin E 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 4-(Azidomethyl)-3-chloropyridine 4,7-Dibromobenzo[c][1,2,5]thiadiazole-5,6-diamine 1-(4-Fluorophenyl)piperidin-2-one Methyl 4-amino-3-(dihexylamino)benzoate 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucito 2-(Tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 6-Bromo-2-methoxy-3-(4-methyl-1H-imidazol-1-yl)pyridineRelated products of tetrahydrofuran
Gramine
1-Methylindole-3-carboxaldehyde
FK 888
1H-Indole-3-carboxamide(9CI)
1H-PYRROLE-3-METHANAMINE, 1-METHYL-
(1-Methyl-1H-indol-3-yl)-methylamine
2-NAPHTHALEN-2-YL-ETHYLAMINE
3-(NAPHTHALEN-2-YL)PROPAN-1-AMINE
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