Fidarestat
- CAS NO.：136087-85-9
- Empirical Formula: C12H10FN3O4
- Molecular Weight: 279.22
- MDL number: MFCD00919183
- EINECS: 200-258-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is Fidarestat?
Biological Activity
Fidarestat (SNK 860) is an aldose reductase inhibitor with IC50 values of 26 nM, 33 μM and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. Fidarestat (SNK 860) has the potential to study diabetes.
in vitro
Fidarestat (SNK-860; 1 or 4 mg/kg. po, daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats.
in vivo
Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively.
Properties of Fidarestat
| Density | 1.61±0.1 g/cm3(Predicted) |
| solubility | DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml |
| form | A crystalline solid |
| pka | 8.46±0.40(Predicted) |
| color | White to off-white |
Safety information for Fidarestat
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Fidarestat
Fidarestat manufacturer
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