Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listFenazox

Fenazox

Synonym(s):Azoxybenzene;Fenazox

  • CAS NO.:61618-27-7
  • Empirical Formula: C15H16NNaO4
  • Molecular Weight: 297.29
  • MDL number: MFCD09842317
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Fenazox Structural

What is Fenazox?

Description

Amfenac sodium is a non-steroidal antiinflammatory agent structurally related to ketoprofen,suprofen(10) and tiaprofenic acid.It is reported to be effective in the short term treatment of rheumatoidarthritis,osteoarthritis and pain associated with minor surgical procedures.

Chemical properties

Yellow Solid

Originator

A.H. Robins (USA)

The Uses of Fenazox

Fenazox is used in the synthetic preparation of amides via reductive amidation of esters, which is used in the synthesis of bio-active molecules and natural products.

The Uses of Fenazox

Amfenac is an antibacterial agent

What are the applications of Application

Amfenac Sodium Salt is an antibacterial agent

Definition

ChEBI: A hydrate that is the monohydrate of the sodium salt of amfenac.

Manufacturing Process

7-Benzoylindolin-2-one:
Method A. A mixture of 2.5 g (0.0077 mole) of ethyl 2-acetamido-3- benzoylphenylacetate in 50 ml of 3 N hydrochloric acid was refluxed for one hour. The reaction mixture was filtered and the filtrate was poured into a mixture of ice and water. The precipitate was collected and recrystallized from acetone; yield of 7-benzoylindolin-2-one 1 g (55%); melting point 154°C.
Method B. A solution of 1.3 g (0.0044 mole) of 2-acetamido-3- benzoylphenylacetic acid in 15 ml of 3 N hydrochloric acid and 15 ml of acetic acid was refluxed for three hours. The cooled solution was poured into ice water and the 7-benzoylindolin-2-one which precipitated was collected and dried.
2-Amino-3-benzoylphenylacetic acid:
A mixture of 1.0 g (0.004 mole) of 7-benzoylindolin-2-one was added to 30 ml of 3 N sodium hydroxide and the basic solution was refluxed for 45 min under nitrogen. The mixture was filtered and the filtrate was neutralized with glacial acetic acid. The precipitate was filtered off, washed with water and dried. The 2-amino-3-benzoylbenzeneacetic acid melted at 122°C (dec.). The yield was 0.8 g (72%).

brand name

FENAZOX

Therapeutic Function

Antiinflammatory

General Description

Amfenac (Fenazox), its amide prodrug, nepafenac (Nevanac),and the related analog, bromofenac, are amphoteric becauseof the presence of an additional aromatic amine group.They are less likely to be absorbed into the general circulation.They are approved for use as topical ocular anti-inflammatoryagents for the treatment of postoperative ocular pain,inflammation, and posterior segment edema. The only observedside effects of these drugs are all related to tissuesaround the eye including abnormal ocular sensation, eye rednessand irritation, burning and stinging, and conjunctival orcornea edema.

Synthesis

The reaction of 1-aminoindolin- 2-one with phenylacetone in presence of acetic acid in refluxing ethanol gives 1-(α- methylphenethylidieneimino)indolin-2-one, which by reaction with refluxing ethanolic hydrogen chloride affords ethyl α-(2-methyl- 3-phenylindol-7-yl)acetate. The ozonolysis of this intermediate in acetic acid yields ethyl 2- acetamido-3-benzoylphenyl acetate, which is cyclized by refluxing with HCl in acetic acid to give 7-benzoylindolin-2-one. Alternatively, the hydrolysis of the ester ethyl α-(2-methyl-3- phenylindol-7-yl)acetate with KOH in refluxing water affords the corresponding acid, which can be ozonolyzed as before yielding 2-acetamido- 3-benzoylphenylacetic acid. This acid can be cyclized to 7-benzoyl-1,3-dihydro-indol-2-one by refluxing with HCl in acetic acid as before .

Properties of Fenazox

Melting point: 242-244°C
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  Methanol (Slightly), Water (Slightly)
form  Solid
color  Yellow

Safety information for Fenazox

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Fenazox

Related products of tetrahydrofuran

You may like

  • 61618-27-7 Amfenac sodium 99%
    61618-27-7 Amfenac sodium 99%
    61618-27-7
    View Details
  • Sodium 2-(2-amino-3-benzoylphenyl)acetate hydrate 95% CAS 61618-27-7
    Sodium 2-(2-amino-3-benzoylphenyl)acetate hydrate 95% CAS 61618-27-7
    61618-27-7
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.