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HomeProduct name listFebuprol

Febuprol

  • CAS NO.:3102-00-9
  • Empirical Formula: C13H20O3
  • Molecular Weight: 224.3
  • MDL number: MFCD00867165
  • EINECS: 221-454-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
Febuprol Structural

What is Febuprol?

Originator

Valbil,Rohm Pharma,W. Germany,1981

Definition

ChEBI: Febuprol is an aromatic ether.

Manufacturing Process

Initially, 4.5 g (0.08 mol) pulverized potassium hydroxide was dissolved in 300 ml isopropanol in a 500 ml four-neck flask equipped with stirrer, intensive cooler, dropping funnel and feed pipe for the gas treatment with nitrogen.
Then, 52.0 g (0.4 mol) n-butylglycidyl ether and 41.4 g (0.44 mol) phenol was added thereto, whereafter the material was heated to boiling under nitrogen. The material was stirred, about 8.5 hours, until no glycidyl ether could be determined, e.g., by gas chromatography.
After the suspension was cooled under nitrogen, the solvent was distilled off under vacuum. The residue was taken up in 200 ml water and the milky emulsion extracted exhaustively with ether. From the organic phase, the excess butylglycidyl ether was extracted with diluted potassium hydroxide solution. The ether phase was washed neutral with water and the solvent removed after drying with sodium sulfate. The remaining oily residue was distilled under vacuum; there was obtained a colorless liquid of BP 123.5°C/0.07 mm. Yield: 81.8 g (91.1% of the theory)

Therapeutic Function

Choleretic

Properties of Febuprol

Melting point: 25°C
Boiling point: bp11 165°; bp1.0 125-132°
Density  d420 1.027
refractive index  nD20 1.5004
storage temp.  2-8°C
CAS DataBase Reference 3102-00-9(CAS DataBase Reference)

Safety information for Febuprol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Febuprol

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