Amino-2-propanol

Synonym(s):(±)-1-Amino-2-propanol;(±)-Isopropanolamine

CAS NO.：78-96-6
Empirical Formula: C3H9NO
Molecular Weight: 75.11
MDL number: MFCD00008139
EINECS: 201-162-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-18 14:08:52

What is Amino-2-propanol?

Chemical properties

colourless liquid

Chemical properties

1-Amino-2-propanol has a fishy odor.

Occurrence

Reportedly present in sherry.

The Uses of Amino-2-propanol

Amino-2-propanol is used to study the effect of temperature and water content on the molecular structure and hydrogen bonding of amino-2-propanol, which has been examined by Fourier transform near-infrared (FT-NIR) spectroscopy. Also used in used in the synthesis of protein kinase CK2 inhibitors used in the treatment of neoplasia and other infective diseases.

The Uses of Amino-2-propanol

Synthetic and semisynthetic machine lubricating/cutting oil formulations have included isopropanolamine, diisopropanolamine, and triethanolamine, together with nitrites; consequently the EPA has promulgated standards regarding the composition of cutting fluids. No additional uses were found in the literature.

The Uses of Amino-2-propanol

Amino-2-propanol can be used as a reactant to prepare:

5-methyl-2-oxazolidinone by oxidative carbonylation reaction using Pd(OAc)₂/I₂ catalyst.
Bio-based polyurethanes by reacting with epoxidized soybean oil via ring-opening and amidation reaction.

It can also be used as a solvent as well as a template to synthesize layered aluminophosphate containing a racemic mixture of isopropanolamine.

Definition

ChEBI: Any amino alcohol that is propan-2-ol substituted by an amino group at position 1.

Preparation

By employing Salmonella, mutatant cobD, and aminopropanol

Aroma threshold values

Detection at 28 ppm in water

General Description

A colorless liquid with a slight ammonia-like odor. Less dense than water and soluble in water. Flash point 165°F. Corrosive to metals and tissue. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in plastics, paints, cutting oils, and specialized cleaning compounds.

Air & Water Reactions

Water soluble.

Reactivity Profile

Amino-2-propanol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Health Hazard

Vapor irritates eyes and nose. Liquid causes local injury to mouth, throat, digestive tract, skin, and eyes.

Fire Hazard

Special Hazards of Combustion Products: Irritating vapors generated when heated.

Safety Profile

Poison by intraperitoneal route.Moderately toxic by ingestion and skin contact. A skin andsevere eye irritant. Moderately flammable in presence ofheat, flame, sparks, powerful oxidizers. Ignites on contactwith cellulose nitrate of high surface area. C

Properties of Amino-2-propanol

Melting point:	-2 °C (lit.)
Boiling point:	160 °C (lit.)
Density	0.973 g/mL at 25 °C (lit.)
vapor density	2.6 (vs air)
vapor pressure	<1 mm Hg ( 20 °C)
FEMA	3965 \| 1-AMINO-2-PROPANOL
refractive index	n20/D 1.4478(lit.)
Flash point:	165 °F
storage temp.	2-8°C
solubility	DMSO : 250 mg/mL (3328.45 mM; Need ultrasonic)
form	Liquid
pka	12.92±0.35(Predicted)
color	Clear
Odor	slt ammonia odor
PH	11.3 (10g/l, H2O, 20℃)
explosive limit	1.9-10.4%(V)
Water Solubility	freely soluble
FreezingPoint	1.4℃
Sensitive	Hygroscopic
JECFA Number	1591
BRN	605275
Stability:	Stable. Substances to be avoided include strong oxidizing agents. Combustible. Hygroscopic.
CAS DataBase Reference	78-96-6(CAS DataBase Reference)
NIST Chemistry Reference	2-Propanol, 1-amino-(78-96-6)
EPA Substance Registry System	Monoisopropanolamine (78-96-6)

Safety information for Amino-2-propanol

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H312:Acute toxicity,dermal H314:Skin corrosion/irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.