EveroliMus-d4
- CAS NO.:1338452-54-2
- Empirical Formula: C53H79D4NO14
- Molecular Weight: 962.249067112
- Update Date: 2024-07-02 08:55:06
What is EveroliMus-d4?
Description
Everolimus-d4 is intended for use as an internal standard for the quantification of everolimus by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation.
The Uses of EveroliMus-d4
Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation.
What are the applications of Application
Everolimus-d4 is a deuterium-labeled derivative of Rapamycin
General Description
A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress? and Certican for use in organ transplantation and Afinitor? for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.
Properties of EveroliMus-d4
storage temp. | Store at 4°C |
solubility | Chloroform: Soluble,Methanol: Soluble |
form | A solid |
color | White to off-white |
Stability: | Hygroscopic |
Safety information for EveroliMus-d4
Computed Descriptors for EveroliMus-d4
New Products
Tubulysin C Tubulysin M Tubulysin A Tubulysin E Potassium HMDS (1.0 M in THF) 2H-Pyran, 4-ethynyltetrahydro- 4,4-DIFLUOROCYCLOHEXANAMINE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 3-N-BOC-(S)-AMINO BUTYRONITRILE 4-(Benzyloxy)-3-bromophenylacetic Acid 2,2-Difluoropropylamine hydrochloride Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (S)-4-(azidomethyl) -3-(3-fluoro-4- thiomorpholino phenyl) oxazolidin-2-one 1-Aminoindan Hydrochloride Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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