2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
- CAS NO.:164162-36-1
- Empirical Formula: C9H19F3O4SSi
- Molecular Weight: 308.39
- MDL number: MFCD22572946
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-10 17:26:08
What is 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate?
The Uses of 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate is used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
The reaction was carried out under a nitrogen atmosphere. TBS- ethylene glycol prepared as per step 1 (85.10g, 0.48 mol) and 2, 6-Lutidine (84.28ml, 0.72 mol) were stirred in n-heptane (425ml) to give a clear solution which was then cooled to -15 to - 25°C. Trifluoromethanesulfonic anhydride (Tf2O) (99.74 ml, 0.590 mol) was added drop-wise over a period of 45 minutes to the n-heptane solution (white precipitate starts to form immediately) while maintaining the reaction at -15 to -25°C. The reaction mixture was kept at temperature between -15 to -25°C for 2 hours. The precipitate generated was filtered off. The filtrate was then evaporated up to ~2 volumes with respect to TBS-ethyiene glycol (~200 ml).
Properties of 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
Boiling point: | 253℃ |
Density | 1.172 |
Flash point: | 107℃ |
Safety information for 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
Computed Descriptors for 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate
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