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HomeProduct name listEtilefrine hydrochloride

Etilefrine hydrochloride

Synonym(s):2-Ethylamino-1-(3-hydroxyphenyl)-1-ethanol hydrochloride

  • CAS NO.:943-17-9
  • Empirical Formula: C10H15NO2.ClH
  • Molecular Weight: 217.69
  • MDL number: MFCD00060167
  • EINECS: 213-398-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-29 17:54:30
Etilefrine hydrochloride  Structural

What is Etilefrine hydrochloride ?

Chemical properties

White or almost white, crystalline powder or colourless crystals.

Originator

Circupon,Troponwerke,W. Germany

The Uses of Etilefrine hydrochloride

Adrenoceptor agonist.

What are the applications of Application

Etilefrine hydrochloride is a useful alkaloid for biological research purposes

Definition

ChEBI: Etilefrine hydrochloride (TN) is a member of phenols.

Manufacturing Process

30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.

Therapeutic Function

Tranquilizer

Properties of Etilefrine hydrochloride

Melting point: 122 °C
storage temp.  -20°C
solubility  Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride
form  neat
form  Solid
color  White to off-white

Safety information for Etilefrine hydrochloride

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.

Computed Descriptors for Etilefrine hydrochloride

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