Etilefrine hydrochloride
Synonym(s):2-Ethylamino-1-(3-hydroxyphenyl)-1-ethanol hydrochloride
- CAS NO.:943-17-9
- Empirical Formula: C10H15NO2.ClH
- Molecular Weight: 217.69
- MDL number: MFCD00060167
- EINECS: 213-398-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-29 17:54:30
What is Etilefrine hydrochloride ?
Chemical properties
White or almost white, crystalline powder or colourless crystals.
Originator
Circupon,Troponwerke,W. Germany
The Uses of Etilefrine hydrochloride
Adrenoceptor agonist.
What are the applications of Application
Etilefrine hydrochloride is a useful alkaloid for biological research purposes
Definition
ChEBI: Etilefrine hydrochloride (TN) is a member of phenols.
Manufacturing Process
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
Therapeutic Function
Tranquilizer
Properties of Etilefrine hydrochloride
Melting point: | 122 °C |
storage temp. | -20°C |
solubility | Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride |
form | neat |
form | Solid |
color | White to off-white |
Safety information for Etilefrine hydrochloride
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Etilefrine hydrochloride
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