Eperisone hydrochloride

Description

Eperisone hydrochloride is a centrally acting muscle relaxant useful in the management of various spastic conditions including cervical spondylosis and cerebral palsy. It is structurally related to tolperisone.

Chemical properties

White Solid

Originator

Eisai (Japan)

The Uses of Eperisone hydrochloride

A spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal).

The Uses of Eperisone hydrochloride

Used as antispasmodic

Definition

ChEBI: Eperisone hydrochloride is an aromatic ketone.

Manufacturing Process

To 60 ml of isopropanol, there are introduced 120 g of 4-ethyl-propiophenone, 28.8g of p-formaldehyde and 107 g of piperidine hydrochloride, and the resulting mixture is heated to reflux on an oil bath with stirring. The heating is continued, and when the reaction mixture solidifies, the state being a sign of completion of the reaction, there are added 500 ml of acetone thereinto. The solidified mass is pulverized by crush, recovered by filtration and washed with acetone. 144 g of the crude dry crystalline substance is thus obtained, which is the hydrochloride of the purposed product. The hydrochloride is recrystallized from isopropanol, and there are obtained the crystalline needles having the melting point of 170°C to 172°C.

brand name

MYONAL

Therapeutic Function

Muscle relaxant

Indications

Eperisone hydrochloride is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex.

Side Effects

Shock and anaphylactoid reactions: In the event of symptoms such as redness, itching, urticaria, oedema of the face and other parts of the body,dyspnoea, etc., treatment should be discontinued and appropriate measures taken.Other side effects: anaemia, rash, pruritus, sleepiness, insomnia, headache, nausea and vomiting, anorexia, abdominal pain, diarrhoea, constipation, urinary retention or incontinence.