Ethylenebis(oxyethylenenitrilo)tetraacetic acid
Synonym(s):EGTA;Glycol ether diamine tetraacetic acid;Egtazic acid;Ethylene Glycol bis (2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid;Ethylene-bis(oxyethylenenitrilo)tetraacetic acid
- CAS NO.：67-42-5
- Empirical Formula: C14H24N2O10
- Molecular Weight: 380.35
- MDL number: MFCD00004291
- EINECS: 200-651-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-24 19:19:26
What is Ethylenebis(oxyethylenenitrilo)tetraacetic acid?
Chemical properties
White to slightly off-white powder
The Uses of Ethylenebis(oxyethylenenitrilo)tetraacetic acid
Pharmaceutic aid. EGTA.
The Uses of Ethylenebis(oxyethylenenitrilo)tetraacetic acid
Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid is a chelating agent used for making complexes, especially for calcium ions, which help to determine calcium in the presence of magnesium. It can be used experimentally for treating animals possessing cerium poisoning. It is useful in the separation of thorium from monazite. It also acts as a buffer and is used in protein purification.
The Uses of Ethylenebis(oxyethylenenitrilo)tetraacetic acid
A chelating agent useful for the determination of calcium in the presence of magnesium.
What are the applications of Application
EGTA is a chelator with specificity for calcium ions used to determine calcium in the presence of magnesium.
Definition
ChEBI: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.
Biological Activity
Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also GLYCOL ETHERS.
storage
Room temperature
Purification Methods
Dissolve EGTA in aqueous NaOH, precipitate it by adding aqueous HCl, wash it with water and dry at 100o in vacuo.[Beilstein 4 IV 217.]
Properties of Ethylenebis(oxyethylenenitrilo)tetraacetic acid
| Melting point: | 241 °C (dec.)(lit.) |
| Boiling point: | 507.99°C (rough estimate) |
| Density | 1.2838 (rough estimate) |
| refractive index | 1.4590 (estimate) |
| storage temp. | room temp |
| solubility | 0.1 M NaOH: 0.1 M at 20 °C, clear, colorless |
| pka | 1.47±0.10(Predicted) |
| form | Crystalline Powder |
| color | White |
| Water Solubility | slightly soluble |
| Merck | 14,3529 |
| BRN | 1717370 |
| CAS DataBase Reference | 67-42-5(CAS DataBase Reference) |
| EPA Substance Registry System | Ethylenebis(oxyethylenenitrilo)tetraacetic acid (67-42-5) |
Safety information for Ethylenebis(oxyethylenenitrilo)tetraacetic acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H303:Acute toxicity,oral |
| Precautionary Statement Codes |
P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P403:Store in a well-ventilated place. |
Computed Descriptors for Ethylenebis(oxyethylenenitrilo)tetraacetic acid
New Products
Tubulysin A Tubulysin F Tubulysin D (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 4,4-DIFLUOROPIPERIDINE 2,2-Difluoropropylamine hydrochloride 4-(Benzyloxy)-3-bromophenylacetic Acid Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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