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HomeProduct name listEthylenebis(oxyethylenenitrilo)tetraacetic acid

Ethylenebis(oxyethylenenitrilo)tetraacetic acid

Synonym(s):EGTA;Glycol ether diamine tetraacetic acid;Egtazic acid;Ethylene Glycol bis (2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid;Ethylene-bis(oxyethylenenitrilo)tetraacetic acid

  • CAS NO.:67-42-5
  • Empirical Formula: C14H24N2O10
  • Molecular Weight: 380.35
  • MDL number: MFCD00004291
  • EINECS: 200-651-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-12 16:52:33
Ethylenebis(oxyethylenenitrilo)tetraacetic acid Structural

What is Ethylenebis(oxyethylenenitrilo)tetraacetic acid?

Chemical properties

White to slightly off-white powder

The Uses of Ethylenebis(oxyethylenenitrilo)tetraacetic acid

Pharmaceutic aid. EGTA.

The Uses of Ethylenebis(oxyethylenenitrilo)tetraacetic acid

Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid is a chelating agent used for making complexes, especially for calcium ions, which help to determine calcium in the presence of magnesium. It can be used experimentally for treating animals possessing cerium poisoning. It is useful in the separation of thorium from monazite. It also acts as a buffer and is used in protein purification.

The Uses of Ethylenebis(oxyethylenenitrilo)tetraacetic acid

A chelating agent useful for the determination of calcium in the presence of magnesium.

What are the applications of Application

EGTA is a chelator with specificity for calcium ions used to determine calcium in the presence of magnesium.

Definition

ChEBI: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.

Biological Activity

Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also GLYCOL ETHERS.

storage

Room temperature

Purification Methods

Dissolve EGTA in aqueous NaOH, precipitate it by adding aqueous HCl, wash it with water and dry at 100o in vacuo.[Beilstein 4 IV 217.]

Properties of Ethylenebis(oxyethylenenitrilo)tetraacetic acid

Melting point: 241 °C (dec.)(lit.)
Boiling point: 507.99°C (rough estimate)
Density  1.2838 (rough estimate)
refractive index  1.4590 (estimate)
storage temp.  room temp
solubility  0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pka 1.47±0.10(Predicted)
form  Crystalline Powder
color  White
Water Solubility  slightly soluble
Merck  14,3529
BRN  1717370
CAS DataBase Reference 67-42-5(CAS DataBase Reference)
EPA Substance Registry System Ethylenebis(oxyethylenenitrilo)tetraacetic acid (67-42-5)

Safety information for Ethylenebis(oxyethylenenitrilo)tetraacetic acid

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H303:Acute toxicity,oral
Precautionary Statement Codes P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P403:Store in a well-ventilated place.

Computed Descriptors for Ethylenebis(oxyethylenenitrilo)tetraacetic acid

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