Ethyl trifluoroacetate

Chemical properties

Colorless to yellow liquid

The Uses of Ethyl trifluoroacetate

Ethyl Trifluoroacetate is an intermediate used in the synthesis of various pharmaceutically active molecules and agricultural products. Ethyl Trifluoroacetate is also useful for the preparation of tri fluoroacylated compounds.

The Uses of Ethyl trifluoroacetate

A solution of the SM (0.411 g, 1.47 mmol) and ethyl trifluoroacetate (0.5 mL, 4.19 mmol) in dry THF was stirred at RT for 15 min. The mixture was concentrated in vacuo to provide the product as a colorless oil, which was used in the next step without further purification. [0.545 g, 99%] [UK Pat App GB2463151A, page 124]

The Uses of Ethyl trifluoroacetate

Widely used in the synthetic process of medicine, pesticides and organic intermediate.

The Uses of Ethyl trifluoroacetate

Ethyl trifluoroacetate is used as an intermediate in organic synthesis to prepare organic fluorine compounds like 3-ethyl-1-methylimidazolium trifluoroacetate (EMITA). It is involved in the syntheses of various pharmaceutically active molecules and agricultural products. It is also useful for the preparation of tri fluoroacylated compounds.

Definition

ChEBI: TRIFLUOROACETIC ACID ETHYL ESTER is an organohalogen compound. It is functionally related to a carboxylic acid.

Preparation

Trifluoroacetic acid and ethanol were used as starting materials with strong-acid cation exchange resin as catalysts at 40 ~ 50 she℃. Add ethanol drop and temperature rising reflux divides the mixture of water and ethanol. After that, collect the mix of thick product ethanol and Ethyl trifluoroacetate. The crude product collected is added a small amount of water, and layering can obtain a content of more than 99.5%. The qualified product Ethyl trifluoroacetate, whose moisture is less than 0.1%, yields more than 95%.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 3527, 1950 DOI: 10.1021/ja01164a056

Flammability and Explosibility

Highly flammable

Purification Methods

Fractionate it through a long Vigreux column (p 11). IR has max at 1800 (CO2) and 1000 (OCO) cm-1 [Fuson et al. J Chem Phys 20 1627 1952, Bergman J Org Chem 23 476 1958]. [Beilstein 2 IV 463.]