Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonym(s):(R)-(−)-4-Cyano-3-hydroxybutyratic acid, ethyl ester
- CAS NO.:141942-85-0
- Empirical Formula: C7H11NO3
- Molecular Weight: 157.17
- MDL number: MFCD00270839
- EINECS: 430-220-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is Ethyl (R)-(-)-4-cyano-3-hydroxybutyate?
Chemical properties
yellow liquid
The Uses of Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Atorvastatin Intermediate
The Uses of Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
analgesic, antipyretic, and anti-inflammatory
The Uses of Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.
What are the applications of Application
Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.
Properties of Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Boiling point: | 270 °C(lit.) |
alpha | -5 º (neat) |
Density | 1.114 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly) |
pka | 13.03±0.20(Predicted) |
form | Liquid |
color | Colorless to yellow |
Specific Gravity | 1.114 |
optical activity | [α]25/D 5°, neat |
BRN | 5328715 |
CAS DataBase Reference | 141942-85-0(CAS DataBase Reference) |
Safety information for Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
InChIKey | LOQFROBMBSKWQY-ZCFIWIBFSA-N |
Abamectin manufacturer
Arch Pharmalabs Ltd
Medec Dragon Private Limited
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