Atorvastatin calcium
Synonym(s):(3 R,5 R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt;(3R,5R)-7-(2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-3,5-dihydroxyheptanoate, hemicalcium salt;(betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrole-1-heptanoate, calcium salt (2:1) trihyddrate;[R-(R*, R*)]-2-(4-Fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1Hpyrrole-1-heptanoic acid, calcium salt (2:1) trihydrate;1H-Pyrrole-1-heptanoic acid, [R-(R*,R*)]-2-(4-flurophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl], calcium salt (2:1)
- CAS NO.:134523-03-8
- Empirical Formula: C33H37CaFN2O5
- Molecular Weight: 600.74
- MDL number: MFCD03613598
- EINECS: 200-659-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-10 16:01:40
What is Atorvastatin calcium?
Description
Lipitor was launched in Canada, the Netherlands, the UK and the US as an orally-active hypocholesterolemic agent. It was the first pharmaceutical product ever to attain over one billion dollars in sales in its first year. It can be synthesized by a number of routes but the most efficient involves the Paal-Knorr reaction of an acetonide protected dihydroxy amino ester and a diaryl phenylacetamide diketone. Lipitor is a liver selective, reversible competitive inhibitor of HMG-CoA reductase, the rate limiting step in cholesterol biosynthesis. Lipitor monotherapy resulted in a reduction of LDL cholesterol by up to 60%. Lipitor is about 2-4 times more potent, on a dosage basis, than Simvastatin. The superior properties of Lipitor can be attributed to its greater uptake and longer duration of action in the liver. In addition to its effects on cholesterol, Lipitor is also effective in lowering triglycerides. While the mechanism is not clear, two theories proposed are: a) the decrease in cholesterol causes a concomitant increase in hepatic LDL-receptor activity (mostly B and E type) which results in a decrease in triglycerides through an increase in binding of triglycerides to VLDL and LDL, and b) the decreased level of cholesterol impairs VLDL transport of triglycerides.
The Uses of Atorvastatin calcium
Atorvastatin Calcium Salt Trihydrate is a compound used as standard in the method development and validation for simultaneous determination of Atorvastatin calcium (A791750) and Ezetimibe (E975000) in tablets using UV spectrophotometric, HPLC and HPTLC methods.
Properties of Atorvastatin calcium
Melting point: | 176-178°C |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | DMSO: ≥10mg/mL |
form | white powder |
color | White to Off-White |
Safety information for Atorvastatin calcium
Computed Descriptors for Atorvastatin calcium
InChIKey | FQCKMBLVYCEXJB-MNSAWQCASA-L |
Abamectin manufacturer
Jigs Chemical ltd
Cadila Pharmaceuticals Ltd
Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd)
Apotex Pharmachem India Pvt Ltd
Macleods Pharmaceuticals Limited
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