ETHYL ISOCYANIDE
- CAS NO.:624-79-3
- Empirical Formula: C3H5N
- Molecular Weight: 55.08
- MDL number: MFCD01740118
- EINECS: 210-863-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 15:12:25
What is ETHYL ISOCYANIDE?
The Uses of ETHYL ISOCYANIDE
Principal use in toxicology was in the characterization of cytochrome P450 isozymes. Ethyl isocyanide and the reduced cytochrome form a characteristic optical difference spectrum with two peaks in the Soret Region (type III). The pH equilibrium point (the pH at which the two peaks are of equal height) varies between different isozymes.
Preparation
CAUTION: The reaction and distillation should be conducted behind a safety shield. Precautions for handling toxic cyanides should be observed.
To a three-necked flask equipped with a condenser and ground glass stirrer (or Hershberg stirrer) is added 116 gm (0.75 mole) of ethyl iodide and 100 gm (0.75 mole) of silver cyanide. The mixture is refluxed for 2 hr, the stirrer blade raised, the mixture cooled, filtered (see Note a), the solid washed with ether, dried, and 260 gm of a 50% solution of potassium cyanide (2.0 moles) added. The reaction mixture is distilled to afford a mixture of isonitrile and water (see Note b). The crude isonitrile 49.5- 52.3 gm (90-95%) is separated after being salted out of the water. The isonitrile is washed twice with 24-ml portions of ice-cold saturated sodium chloride solution, dried over magnesium sulfate, and fractionally distilled, to afford 25.9-30.3 gm (47-55%), b.p. 77-79°C (760 mm Hg).
Properties of ETHYL ISOCYANIDE
Boiling point: | 96.85°C (estimate) |
Density | 0.7378 |
refractive index | 1.3607 |
Water Solubility | 999mg/L(temperature not stated) |
EPA Substance Registry System | Ethane, isocyano- (624-79-3) |
Safety information for ETHYL ISOCYANIDE
Computed Descriptors for ETHYL ISOCYANIDE
New Products
(R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin F Tubulysin E Tubulysin B Tubulysin C Tubulysin D Potassium HMDS (1.0 M in THF) 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID tetrahydro-4-methyl-2H-pyran 3-Aminocyclobutanone hydrochloride Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 4-(Benzyloxy)-3-bromophenylacetic Acid 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 5-Piperazin-1-yl- benzofuran-2- carboxylic acid ethyl ester. HCl 2,3-dichloro-6- nitrobenzonitrile Magnesium Trisilicate Latanoprostene Bunod LubiprostoneRelated products of tetrahydrofuran
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