I-PROPYLISOCYANIDE
- CAS NO.:598-45-8
- Empirical Formula: C4H7N
- Molecular Weight: 69.11
- MDL number: MFCD00015503
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is I-PROPYLISOCYANIDE?
The Uses of I-PROPYLISOCYANIDE
Isopropyl isocyanide may be used in the preparation of:
- Ugi ligand A2C11I1, which is employed in the solid-phase Ugi synthesis.
- Pentafluorophenyl (PFP) functional monomers, via Passerini reaction.
- Dinuclear copper complex [Cu2(μ-PiPr2bipy)2{μ-CNCH(CH3)2}](PF6)2 [PiPr2bipy = 6-(diisopropylphosphanyl)-2,2′-bipyridine].
- (3E)-(Imino)thiaisoindoline 1,1-dioxide derivative.
- N,N′-diisopropylcarbodiimide (DIC) analog via reaction with propan-2-amine.
- 1-t-butyl-2-isopropyldiaziridinone via reaction with 2-methyl-2-nitrosopropane
- isopropyl isocyanate via reaction with ozone
- 1-phthalimidoazetidines via [1+3]cycloaddition reaction with 1-pththalimidoaziridines
Preparation
To a flask containing 100 ml (0.85 mole) of distilled quinoline is added with stirring 41 gm (0.214 mole) of /7-toluenesulfonyl chloride (see Note), and the solution is warmed to 75°C. Then 18.4 gm (0.212 mole) of isopropylformamide is added and the pressure of the system is reduced to 70 mm Hg. The isopropylisonitrile as it forms distills into a liquid nitrogencooled receiver. (Dry ice is not as effective but may be used.) The product is redistilled to afford 4.2 gm (30%), b.p. 88-89°C (735 mm Hg).
General Description
Isopropyl isocyanide is an alkyl isocyanide.
Properties of I-PROPYLISOCYANIDE
Boiling point: | 75 °C(lit.) |
Density | 0.733 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 69 °F |
storage temp. | 2-8°C |
form | liquid |
color | colorless |
Specific Gravity | 0.7596 |
Stability: | store cold |
Safety information for I-PROPYLISOCYANIDE
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H225:Flammable liquids |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
Computed Descriptors for I-PROPYLISOCYANIDE
New Products
Tubulysin H Tubulysin G Tubulysin E 2,2-diethoxyethanethioamide (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Diethyl Aluminium Cyanide (1.0 M in Toluene) 2,2-Difluoropropylamine hydrochloride 2H-Pyran, 4-ethynyltetrahydro- 4,4-DIFLUOROCYCLOHEXANAMINE CYCLOBUTYLAMINE HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- Calcium Sodium Phosphosilicate IH Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamateRelated products of tetrahydrofuran
CYCLOHEXYL ISOCYANIDE
5-METHYLHEX-2-YLISOCYANIDE
2-ISOCYANO-OCTANE
TERT-AMYLISOCYANIDE
CYCLOOCTYLISOCYANIDE
aerocyanidin
3-ISOCYANOOCTANE
(1-Isocyanoethyl)benzene
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