Ethyl 4-hydroxypiperidine-1-carboxylate
- CAS NO.:65214-82-6
- Empirical Formula: C8H15NO3
- Molecular Weight: 173.21
- MDL number: MFCD00086880
- EINECS: 265-636-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-24 21:11:45
What is Ethyl 4-hydroxypiperidine-1-carboxylate?
Chemical properties
Colorless liquid
The Uses of Ethyl 4-hydroxypiperidine-1-carboxylate
Ethyl 4-hydroxypethidine-1-carboxylate is mainly used as a pharmaceutical intermediate and a raw material for organic matter. It can be used in the synthesis of antihistamines, antipsychotics, antidepressants, and various pesticides. As an intermediate, the compound can also produce fungicides and insecticides. It can be used as a raw material for synthetic surfactants, flavors, and fragrances.
Preparation
Add triethylamine (1.5 equivalent) and ethyl chlorine 4-hydroxypiperidine-1-carboxylate (1.2 equivalent) to the dichloromethane solution of 4-hydroxypiperidine (1.0 equivalent) at 0 °C. Stir the mixture at 0 °C for 30 min. The reaction mixture is then poured into water and extracted with methylene chloride. Wash organic extracts with water and salt water. The compound is placed on sodium sulfate to dry. Finally, the organic extract is concentrated under reduced pressure to obtainEthyl 4-hydroxypiperidine-1-carboxylate.
Properties of Ethyl 4-hydroxypiperidine-1-carboxylate
Boiling point: | 120-130 °C(Press: 0.098 Torr) |
Density | 1.12 |
refractive index | 1.4802 |
storage temp. | Inert atmosphere,Room Temperature |
pka | 14.80±0.20(Predicted) |
form | clear liquid |
color | Colorless to Light yellow to Light orange |
InChI | InChI=1S/C8H15NO3/c1-2-12-8(11)9-5-3-7(10)4-6-9/h7,10H,2-6H2,1H3 |
CAS DataBase Reference | 65214-82-6(CAS DataBase Reference) |
Safety information for Ethyl 4-hydroxypiperidine-1-carboxylate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Ethyl 4-hydroxypiperidine-1-carboxylate
InChIKey | QABJNOSERNVHDY-UHFFFAOYSA-N |
SMILES | N1(C(OCC)=O)CCC(O)CC1 |
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