Ethyl 4-bromobutyrate

CAS NO.：2969-81-5
Empirical Formula: C6H11BrO2
Molecular Weight: 195.05
MDL number: MFCD00000259
EINECS: 221-005-6
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is Ethyl 4-bromobutyrate?

Description

Ethyl 4-bromobutyrate is a colourless volatile liquid organic or biological reagent. It is used in organic synthesis to prepare 4-bromobutyl ester, 4-bromobutyl amide and 4-bromobutyl ether. It is also used in the synthesis of poly(2,6-dimethyl-1,4-epoxyphenyl ether) and isotopic thieno[2,3-b]azepin-4-one thieno[2,3-b]-azepin-4-one with antitumour activity. In the biological field, it has been used in enzyme-linked immunosorbent assays for zilpaterol.

Chemical properties

clear colorless to yellow liquid

The Uses of Ethyl 4-bromobutyrate

Ethyl 4-bromobutyrate is used as a building block for the preparation of firefly luciferase inhibitor-conjucated peptide derivatives. It finds application in the synthesis of poly(2,6,-dimethyl-1,4-phehylene oxide) and thieno(2,3-b)-azepin-4-ones.

The Uses of Ethyl 4-bromobutyrate

A versatile building block and synthesis reagent

Synthesis Reference(s)

The Journal of Organic Chemistry, 56, p. 2264, 1991 DOI: 10.1021/jo00006a061

Hazard

Strongly irritating to skin and eyes

Properties of Ethyl 4-bromobutyrate

Melting point:	98-100 °C
Boiling point:	80-82 °C/10 mmHg (lit.)
Density	1.363 g/mL at 25 °C (lit.)
refractive index	n20/D 1.456(lit.)
Flash point:	195 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Sparingly)
form	Liquid
color	Clear colorless to yellow
Specific Gravity	1.363
Water Solubility	immiscible
BRN	1749700
CAS DataBase Reference	2969-81-5(CAS DataBase Reference)
NIST Chemistry Reference	Ethyl 4-bromobutyrate(2969-81-5)

Safety information for Ethyl 4-bromobutyrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.