Ethyl 2-oxo-4-phenylbutyrate

CAS NO.：64920-29-2
Empirical Formula: C12H14O3
Molecular Weight: 206.24
MDL number: MFCD00037533
EINECS: 265-276-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 16:48:35

What is Ethyl 2-oxo-4-phenylbutyrate ?

Chemical properties

light yellow oily liquid

The Uses of Ethyl 2-oxo-4-phenylbutyrate

Ethyl 2-oxo-4-phenylbutyrate may be used in the synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate, an important chiral precursor for angiotensin-converting enzyme (ACE) inhibitor.

General Description

Ethyl 2-oxo-4-phenylbutyrate is an aliphatic α-ketoester. Bioreduction of ethyl 2-oxo-4-phenylbutyrate is reported to yield ethyl (R)-2-hydroxy-4-phenylbutanoate. The effect of ionic liquid on the asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate by Saccharomyces cerevisiae has been reported. Asymmetric reduction of ethyl 2-oxo-4-phenylbutyrate using a bacterial reductase is reported. Enantioselective hydrogenation of ethyl 2-oxo-4-phenylbutyrate using homogeneous Rh-diphosphine and heterogeneous Pt/Al₂O₃-cinchona catalysts has been reported.

Properties of Ethyl 2-oxo-4-phenylbutyrate

Boiling point:	132 °C/2 mmHg (lit.)
Density	1.091 g/mL at 25 °C (lit.)
refractive index	n20/D 1.504(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Oil
color	Colourless
BRN	2725083
CAS DataBase Reference	64920-29-2(CAS DataBase Reference)

Safety information for Ethyl 2-oxo-4-phenylbutyrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.