ETHYL 2-FLUOROACETOACETATE
Synonym(s):2-Fluoro-3-oxobutanoic acid ethyl ester;Ethyl 2-fluoro-3-oxobutanoate;Ethyl 2-fluoro-3-oxobutyrate;NSC 24563
- CAS NO.：1522-41-4
- Empirical Formula: C6H9FO3
- Molecular Weight: 148.13
- MDL number: MFCD00215830
- EINECS: 629-671-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 17:06:37
What is ETHYL 2-FLUOROACETOACETATE?
Chemical properties
Clear colorless liquid
The Uses of ETHYL 2-FLUOROACETOACETATE
Reactant for:
- Michael addition-induced cyclization reaction
- Asymmetric Mannich reaction
- Enantioselective organocatalytic conjugate addition
Synthesis Reference(s)
Tetrahedron, 54, p. 2867, 1998 DOI: 10.1016/S0040-4020(98)83023-8
General Description
Ethyl 2-fluoroacetoacetate is an α-fluorinated β-keto ester that can be prepared by the fluorination of ethyl acetoacetate.
Properties of ETHYL 2-FLUOROACETOACETATE
| Boiling point: | 183 °C (lit.) |
| Density | 1.181 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 194 °F |
| form | Liquid |
| pka | 9.25±0.46(Predicted) |
| color | Clear colorless to pale yellow |
| CAS DataBase Reference | 1522-41-4(CAS DataBase Reference) |
Safety information for ETHYL 2-FLUOROACETOACETATE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ETHYL 2-FLUOROACETOACETATE
| InChIKey | SHTFQLHOTAJQRJ-UHFFFAOYSA-N |
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