ERYTHROMYCIN A DIHYDRATE

CAS NO.：59319-72-1
Empirical Formula: C37H67NO13.H2O
Molecular Weight: 751.945
MDL number: MFCD00144254
EINECS: 204-040-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-23 13:52:06

What is ERYTHROMYCIN A DIHYDRATE?

Biological Activity

Erythromycin dihyrate is a macrolide antibiotic produced by actinomycetes with broad antibacterial activity. It acts by binding to the bacterial 50S ribosomal subunit and inhibits RNA-dependent protein synthesis by blocking transpeptidation and/or translocation reactions without affecting nucleic acid synthesis .

in vitro

Erythromycin dihyrate inhibits growth of P. falciparum with IC ₅₀ and IC ₉₀ values of 58.2 μM and 104.0 μM, respectively .

in vivo

Mice of the ddY strain began to receive Erythromycin dihyrate 7 days after inoculation of EAC cells, and CDF mice begins to receive Erythromycin dihyrate immediately after inoculation of P388 cells. Erythromycin dihyrate (gastric intubation; 0.1-50 mg/ kg; 30-120 days) decreases tumor growth from the dose of 5 mg/kg, mice receiving 1-10 mg/kg of Erythromycin dihyrate survives much longer than control mice, Only 10% of mice treated with 5 mg/kg of Erythromycin dihyrate had no evidence of tumor formation on day 60, and the mice are alive even at 120 days after inoculation. However, treatment with 50 mg/kg of Erythromycin dihyrate shortens mean survival time in tumorbearing mice by 4-5 days when it compares to controls.

Animal Model:	Female ddY mice at the age of 6 weeks with EAC cells or CDF mice at the age of 6 weeks with P388 ce lls
Dosage:	0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg
Administration:	Gastric intubation; 30-120 days
Result:	Decrease tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortens the MST in tumorbearing mice.