(S)-Equol
- CAS NO.:531-95-3
- Empirical Formula: C15H14O3
- Molecular Weight: 242.27
- MDL number: MFCD00200962
- EINECS: 208-522-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-05 19:05:58
What is (S)-Equol?
Chemical properties
White to Off-White Solid
The Uses of (S)-Equol
(S)-Equol and R-Equol are metabolites of the soy isoflavones Daidzein (D103500) and Genistein. Both have significant biological actions.
The Uses of (S)-Equol
Receptor; binding activity
The Uses of (S)-Equol
A human urinary metabolite of Daidzein. It is also a natural estrogenic metabolite from soy isoflavones
The Uses of (S)-Equol
serine protease
What are the applications of Application
(S)-Equol is a non-steroidal ERβ agonist
Definition
ChEBI: Equol is a member of hydroxyisoflavans.
Biological Activity
equol is an isoflavan produced by intestinal bacteria in response to soy isoflavone intake in human. it shows a wide range of activities including antioxidant activity, anti-inflammation activity and anticancer activity. it is reported that equol specifically binds to 5α-dht and has a modest affinity for recombinant estrogen receptor erβ, which may be responsible for most of equol’s biological properties. [1]
in vitro
in vitro studies were conducted to measure both the binding affinity of equol for 5alpha-dihydrotestosterone (5alpha-dht) and the effects of equol treatment in human prostate cancer (lncap) cells. it was found that equol bound to 5alpha-dht with maximum and half maxim concentrations of 100 nm and 4.8 nm, respectively. in addition, equol significantly offset the increases in psa levels from lncap cells. [1]
in vivo
an in vivo study was performed to investigate effects of equol on rat prostate weight and circulating levels of sex steroid hormones. 1.0 mg/kg of equol was injected to long-evans rats fed with a low isoflavone diet for 25 days. findings from this study suggested that equol significantly decreased rat prostate weights and down-regulated serum levels of 5alpha-dht. however, this agent did not alter levels of lh, testosterone and estradiol. [1]
References
[1]lund td, blake c, bu l, hamaker an, lephart ed. iequol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence. reprod biol endocrin. 2011; 9(4): doi: 10.1186/1477-7827-9-4.
[2]setchell dr and clerici c. equol: pharmacokinetics and biological actions. j nutr. 2010 jul; 140(7): 1363s–8s.
Properties of (S)-Equol
Melting point: | 189-190°C |
Boiling point: | 312.25°C (rough estimate) |
alpha | D -21.5° |
Density | 1.1914 (rough estimate) |
refractive index | 1.5557 (estimate) |
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO (Soluble), Ethanol (Slightly), Methanol (Slightly) |
form | Solid |
pka | 9.94±0.40(Predicted) |
color | White to Pale Yellow |
CAS DataBase Reference | 531-95-3(CAS DataBase Reference) |
Safety information for (S)-Equol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (S)-Equol
Abamectin manufacturer
Anthem Biosciences Pvt Ltd
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