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HomeProduct name listEntecavir hydrate

Entecavir hydrate

Synonym(s):2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate

  • CAS NO.:209216-23-9
  • Empirical Formula: C12H17N5O4
  • Molecular Weight: 295.3
  • MDL number: MFCD09754448
  • EINECS: 606-668-5
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
Entecavir hydrate Structural

What is Entecavir hydrate?

The Uses of Entecavir hydrate

Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir hydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the vira

The Uses of Entecavir hydrate

Entecavir Monohydrate could be a useful compound for treating hepatitis virus B infection.

Definition

ChEBI: The monohydrate form of entecavir. A synthetic analogue of 2'-deoxyguanosine, entecavir is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. It is phosphorylated intracellularly to the active triphosp ate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. Enteclavir is used for the treatment of c ronic hepatitis B.

brand name

Baraclude (Bristol-Myers Squibb).

Description

Entecavir hydrate is the monohydrate form of entecavir.  A synthetic analogue of 2'-deoxyguanosine, entecavir is a nucleoside  reverse transcriptase inhibitor with selective antiviral activity  against hepatitis B virus.

Properties of Entecavir hydrate

Melting point: >220°
alpha  D +35.0° (c = 0.38 in water)
Density  1.81
storage temp.  Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility  DMSO (Slightly), Methanol (Sparingly), Water (Slightly, Heated, Sonicated)
form  Solid
color  White to Off-White
Merck  14,3595
CAS DataBase Reference 209216-23-9(CAS DataBase Reference)

Safety information for Entecavir hydrate

Signal word Danger
Pictogram(s)
ghs
Health Hazard
GHS08
GHS Hazard Statements H351:Carcinogenicity
H372:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Entecavir hydrate

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