Entecavir hydrate

Synonym(s):2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate

CAS NO.：209216-23-9
Empirical Formula: C12H17N5O4
Molecular Weight: 295.3
MDL number: MFCD09754448
EINECS: 606-668-5
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is Entecavir hydrate?

The Uses of Entecavir hydrate

Entecavir hydrate is an oral antiviral drug used in the treatment of hepatitis B infection. Entecavir hydrate is a nucleoside analog (more specifically, a guanine analogue) that inhibits reverse transcription, DNA replication and transcription in the vira

The Uses of Entecavir hydrate

Entecavir Monohydrate could be a useful compound for treating hepatitis virus B infection.

Definition

ChEBI: The monohydrate form of entecavir. A synthetic analogue of 2'-deoxyguanosine, entecavir is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. It is phosphorylated intracellularly to the active triphosp ate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. Enteclavir is used for the treatment of c ronic hepatitis B.

brand name

Baraclude (Bristol-Myers Squibb).

Description

Entecavir hydrate is the monohydrate form of entecavir. A synthetic analogue of 2'-deoxyguanosine, entecavir is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus.

Properties of Entecavir hydrate

Melting point:	>220°
alpha	D +35.0° (c = 0.38 in water)
Density	1.81
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	DMSO (Slightly), Methanol (Sparingly), Water (Slightly, Heated, Sonicated)
form	Solid
color	White to Off-White
Merck	14,3595
CAS DataBase Reference	209216-23-9(CAS DataBase Reference)

Safety information for Entecavir hydrate

Signal word	Danger
Pictogram(s)	Health Hazard GHS08
GHS Hazard Statements	H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P308+P313:IF exposed or concerned: Get medical advice/attention.