Encainide
- CAS NO.:37612-13-8
- Empirical Formula: C22H28N2O2
- Molecular Weight: 352.475
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-19 15:37:51
What is Encainide?
Description
Encainide is a membrane-active class I c agent with complex metabolism and clinical pharmacology , . To date, its effectiveness has been proved against ventricular arrhythmias.
The Uses of Encainide
Clinical use of encainide is primarily associated with the presence of serious ventricular tachycardia; however, like flecainide, it is also sufficiently effective for atrial arrhythmia and is used for natural occurrences.
The Uses of Encainide
Cardiac depressant (anti-arrhythmic.
Definition
ChEBI: Encainide is 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a member of piperidines and a member of benzamides.
brand name
Enkaid (Bristol Labs).
World Health Organization (WHO)
The membrane-stabilizing antiarrhythmic agent encainide was introduced into medicine in the mid-1980's. The decision to delete the indications for patients with asymptomatic and less severe symptomatic ventricular arrhythmias was taken on the basis of the results of a trial (CAST study) that showed a two-fold increase in deaths in post-myocardiac patients taking encainide compared with the placebo group. (See also WHO comment for flecainide).
Side Effects
Side effects include central nervous system activity.
Synthesis
Encainide, 4-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-benzamide (18.1.15), is synthesized by acylating 2-(1-methyl-2-piperidylethyl)aniline with 4- methoxybenzoic acid chloride. The chemical structure of encainide is substantially different than other local anesthetics and antiarrhythmics.
Safety information for Encainide
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin D Tubulysin C Tubulysin H 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 5-Aminophthalazine 4-(Azidomethyl)-3-chloropyridine 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 4,8-dibromo-5H-[1,2,3]triazolo[4',5':4,5]benzo[1,2-c][1,2,5]thiadiazole 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (-)-1-Phenyl ethane sulfonic acid 6-Hydroxyisoquinoline 3-(4-bromo-1H-pyrazol-1-yl)-N,N-dimethylpropanamide 6-bromo-4-methyl-2-propyl-1H-1,3-benzodiazoleRelated products of tetrahydrofuran
You may like
-
3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dioneView Details
952145-70-9 -
1262243-12-8View Details
1262243-12-8 -
Rimegepant Impurity 3View Details
-
Sidchem 730View Details
-
Sidchem BT 20View Details
-
1572177-89-9View Details
1572177-89-9 -
6390-09-6View Details
6390-09-6 -
6-Bromo indoleView Details