Encainide
- CAS NO.:37612-13-8
- Empirical Formula: C22H28N2O2
- Molecular Weight: 352.475
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-19 15:37:51
What is Encainide?
Description
Encainide is a membrane-active class I c agent with complex metabolism and clinical pharmacology , . To date, its effectiveness has been proved against ventricular arrhythmias.
The Uses of Encainide
Clinical use of encainide is primarily associated with the presence of serious ventricular tachycardia; however, like flecainide, it is also sufficiently effective for atrial arrhythmia and is used for natural occurrences.
The Uses of Encainide
Cardiac depressant (anti-arrhythmic.
Definition
ChEBI: Encainide is 4-Methoxy-N-phenylbenzamide in which the hydrogen at the 2 position of the phenyl group is substituted by a 2-(1-methylpiperidin-2-yl)ethyl group. A class Ic antiarrhythmic, the hydrochloride was used for the treatment of severe or life-threatening ventricular arrhythmias, but it was associated with increased death rates in patients who had asymptomatic heart rhythm abnormalities after a recent heart attack and was withdrawn from the market. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a member of piperidines and a member of benzamides.
brand name
Enkaid (Bristol Labs).
World Health Organization (WHO)
The membrane-stabilizing antiarrhythmic agent encainide was introduced into medicine in the mid-1980's. The decision to delete the indications for patients with asymptomatic and less severe symptomatic ventricular arrhythmias was taken on the basis of the results of a trial (CAST study) that showed a two-fold increase in deaths in post-myocardiac patients taking encainide compared with the placebo group. (See also WHO comment for flecainide).
Side Effects
Side effects include central nervous system activity.
Synthesis
Encainide, 4-methoxy-N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-benzamide (18.1.15), is synthesized by acylating 2-(1-methyl-2-piperidylethyl)aniline with 4- methoxybenzoic acid chloride. The chemical structure of encainide is substantially different than other local anesthetics and antiarrhythmics.
Safety information for Encainide
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