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HomeProduct name listECHINACOSIDE

ECHINACOSIDE

  • CAS NO.:82854-37-3
  • Empirical Formula: C35H46O20
  • Molecular Weight: 786.73
  • MDL number: MFCD00075695
  • EINECS: 240-851-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-09 16:05:57
ECHINACOSIDE Structural

What is ECHINACOSIDE?

Description

Echinacoside is a phenylethanoid glycoside that has been found in Echinacea and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals (EC50 = 6.6 μM in a cell-free assay). Echinacoside (10 μg/ml) inhibits hydrogen peroxide-induced production of reactive oxygen species (ROS) and apoptosis in PC12 cells. It reduces increases in plasma alanine aminotransferase (ALT), TNF-α, IL-1β, IL-16, and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury when administered at a dose of 60 mg/kg. Echinacoside (20 mg/kg per day for 15 days) prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in a mouse model of MPTP-induced Parkinson''s disease. It also improves motor performance in the rotarod test in the same model.

Chemical properties

White powder

The Uses of ECHINACOSIDE

Echinacoside Ethanolate is a caffeic acid glycoside, known for its neuroprotective, antiinflammatory and anti-oxidative activities. Also an anti[proliferative towards hypoxia influenced pulmonary artery smooth muscle cells.

What are the applications of Application

Echinacoside is a specialty product for proteomics research

Definition

ChEBI: Echinacoside is an oligosaccharide.

Properties of ECHINACOSIDE

Boiling point: 1062.7±65.0 °C(Predicted)
Density  1.66±0.1 g/cm3(Predicted)
storage temp.  Inert atmosphere,2-8°C
solubility  DMSO:60.0(Max Conc. mg/mL);76.26(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.13(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);38.13(Max Conc. mM)
Ethanol:52.5(Max Conc. mg/mL);66.73(Max Conc. mM)
Water:24.36(Max Conc. mg/mL);30.96(Max Conc. mM)
pka 8.43±0.20(Predicted)
form  powder
color  White-beige
BRN  4778612
Stability: Hygroscopic

Safety information for ECHINACOSIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for ECHINACOSIDE

InChIKey FSBUXLDOLNLABB-ISAKITKMSA-N

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