ECHINACOSIDE
- CAS NO.:82854-37-3
- Empirical Formula: C35H46O20
- Molecular Weight: 786.73
- MDL number: MFCD00075695
- EINECS: 240-851-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-06 15:28:16
What is ECHINACOSIDE?
Description
Echinacoside is a phenylethanoid glycoside that has been found in Echinacea and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals (EC50 = 6.6 μM in a cell-free assay). Echinacoside (10 μg/ml) inhibits hydrogen peroxide-induced production of reactive oxygen species (ROS) and apoptosis in PC12 cells. It reduces increases in plasma alanine aminotransferase (ALT), TNF-α, IL-1β, IL-16, and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury when administered at a dose of 60 mg/kg. Echinacoside (20 mg/kg per day for 15 days) prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in a mouse model of MPTP-induced Parkinson''s disease. It also improves motor performance in the rotarod test in the same model.
Chemical properties
White powder
The Uses of ECHINACOSIDE
Echinacoside Ethanolate is a caffeic acid glycoside, known for its neuroprotective, antiinflammatory and anti-oxidative activities. Also an anti[proliferative towards hypoxia influenced pulmonary artery smooth muscle cells.
Definition
ChEBI: Echinacoside is an oligosaccharide.
What are the applications of Application
Echinacoside is a specialty product for proteomics research
Properties of ECHINACOSIDE
Boiling point: | 1062.7±65.0 °C(Predicted) |
Density | 1.66±0.1 g/cm3(Predicted) |
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO:60.0(Max Conc. mg/mL);76.26(Max Conc. mM) DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.13(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);38.13(Max Conc. mM) Ethanol:52.5(Max Conc. mg/mL);66.73(Max Conc. mM) Water:24.36(Max Conc. mg/mL);30.96(Max Conc. mM) |
pka | 8.43±0.20(Predicted) |
form | powder |
color | White-beige |
BRN | 4778612 |
Stability: | Hygroscopic |
Safety information for ECHINACOSIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ECHINACOSIDE
InChIKey | FSBUXLDOLNLABB-ISAKITKMSA-N |
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