E3 ligase Ligand-Linker Conjugates 7 Free Base

CAS NO.：2010159-57-4
Empirical Formula: C32H49N5O8S
Molecular Weight: 663.83
MDL number: MFCD31656715
Update Date: 2024-11-08 20:21:46

What is E3 ligase Ligand-Linker Conjugates 7 Free Base?

Description

(S, R, S)-AHPC-PEG4-amine is a PROTAC linker that incorporates an E3 ligase ligand with a PEG4 unit to empower drug research & discovery. The amine group is reactive with NHS ester or carboxylic acid.

The Uses of E3 ligase Ligand-Linker Conjugates 7 Free Base

Protein degrader builiding block (S,R,S)-AHPC-PEG₄-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Properties of E3 ligase Ligand-Linker Conjugates 7 Free Base

Boiling point:	901.7±65.0 °C(Predicted)
Density	1.230±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in Water, DMSO, Methanol
pka	13.54±0.46(Predicted)
form	Solid
color	White to off-white

Safety information for E3 ligase Ligand-Linker Conjugates 7 Free Base

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.