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HomeProduct name listE3 ligase Ligand-Linker Conjugates 11

E3 ligase Ligand-Linker Conjugates 11

Synonym(s):(S,R,S)-AHPC-6-5-6-Cl;(2S,4R)-1-((S)-2-(6-((5-((6-Chlorohexyl)oxy)pentyl)oxy)hexanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;Crosslinker–E3 Ligase ligand conjugate;Protein degrader building block for PROTAC research;Template for synthesis of targeted protein degrader

  • CAS NO.:1835705-61-7
  • Empirical Formula: C39H61ClN4O6S
  • Molecular Weight: 749.44
  • MDL number: MFCD31560481
  • Update Date: 2024-10-28 23:16:16
E3 ligase Ligand-Linker Conjugates 11 Structural

What is E3 ligase Ligand-Linker Conjugates 11?

The Uses of E3 ligase Ligand-Linker Conjugates 11

Protein degrader builiding block (S,R,S)-AHPC-C6-PEG1-C3-PEG1-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Properties of E3 ligase Ligand-Linker Conjugates 11

Boiling point: 921.3±65.0 °C(Predicted)
Density  1.152±0.06 g/cm3(Predicted)
storage temp.  2-8°C
pka 14.08±0.40(Predicted)
form  Solid
color  Off-white to yellow

Safety information for E3 ligase Ligand-Linker Conjugates 11

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for E3 ligase Ligand-Linker Conjugates 11

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