DOTA
Synonym(s):DOTA
- CAS NO.：60239-18-1
- Empirical Formula: C16H28N4O8
- Molecular Weight: 404.42
- MDL number: MFCD00068657
- EINECS: 611-959-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-29 11:48:30
What is DOTA?
Chemical properties
Colourless crystals
The Uses of DOTA
Bifunctional DOTA aconjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and ther apeutic radiopharmaceuticals.
The Uses of DOTA
1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) is a macrocyclic complexing agent.
- It has been used for radiolabeling of carbon nanotube bioconjugates by chelating 64Cu radioisotope.
- DOTA can be activated with N-hydroxysulfosuccinimidyl for conjugation with monoclonal antibodies in clinical radioimmunotherapy.
- It can form complexes with gadolinium for application as MRI contrast agents.
- Metal complexes of DOTA-peptide conjugates can be used as therapeutic radiopharmaceuticals.
Definition
ChEBI: An azamacrocyle in which four nitrogen atoms at positions 1, 4, 7 and 10 of a twelve-membered ring are each substituted with a carboxymethyl group.
Properties of DOTA
| Melting point: | 267 °C |
| Boiling point: | 701.6±60.0 °C(Predicted) |
| Density | 1.321 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Water (Slightly, Heated), Methanol (Slightly) |
| pka | 2.16±0.10(Predicted) |
| form | Powder |
| color | white |
| BRN | 1186987 |
| Stability: | Hygroscopic |
Safety information for DOTA
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DOTA
Abamectin manufacturer
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