Domiphen bromide
Synonym(s):(Dodecyldimethyl-2-phenoxyethyl)ammonium bromide
- CAS NO.:538-71-6
- Empirical Formula: C22H40BrNO
- Molecular Weight: 414.46
- MDL number: MFCD00011769
- EINECS: 208-702-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:07
What is Domiphen bromide?
Description
Domiphen is a quaternary ammonium compound and cationic surfactant with antimicrobial activity. It is active against A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes bacteria and inhibits C. neoformans yeast growth and spore germination. It also inhibits the human-ether-a-go-go-related gene (hERG) channel (IC50 = 1.5 μM in a whole-cell patch-clamp assay). Formulations containing domiphen have been used as antiseptics, disinfectants, and biocides in industrial, agricultural, veterinary, and clinical applications.
Originator
Bradosol,Ciba,US,1958
The Uses of Domiphen bromide
Domiphen bromide is employed as a phase transfer catalyst in synthetic chemistry. It is used as a quaternary ammonium cation with cationic surfactant properties. Further, it is used as an antiseptic and an active pharmaceutical ingredient.
The Uses of Domiphen bromide
Antiinfective, topical.
What are the applications of Application
Domiphen bromide is a quaternary ammonium with cationic surfactant properties
Definition
ChEBI: Domiphen bromide is an aromatic ether.
Manufacturing Process
7 parts of β-phenoxyethyl-dimethylamine are heated for 2 hours on the boiling water-bath with 11 parts of dodecyl bromide. A good yield of β-phenoxy-ethyldimethyl-dodecyl-ammonium bromide is obtained which, after recrystallization from acetone, melts at 112°C. It is a white crystalline powder which dissolves easily in water to give a neutral reaction.
Therapeutic Function
Topical antiinfective
Safety Profile
Poison by intraperitoneal and intravenous routes. hfutauon data reported. When heated to decomposiuon it emits very toxic fumes of NOx, NH3, and Br-. See also BROMIDES.
Properties of Domiphen bromide
Melting point: | 117-119 °C (lit.) |
Density | 1.1411 (rough estimate) |
refractive index | 1.5570 (estimate) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
form | Solid |
color | White to Off-White |
Water Solubility | Soluble in ethanol, acetone, ethyl acetate, chloroform and water. Slightly soluble in benzene. |
Sensitive | Hygroscopic |
Merck | 14,3415 |
BRN | 3922742 |
CAS DataBase Reference | 538-71-6(CAS DataBase Reference) |
EPA Substance Registry System | 1-Dodecanaminium, N,N-dimethyl-N-(2-phenoxyethyl)-, bromide (1:1) (538-71-6) |
Safety information for Domiphen bromide
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Domiphen bromide
InChIKey | OJIYIVCMRYCWSE-UHFFFAOYSA-M |
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