Dolutegravir Impurity 3
- CAS NO.:1973402-05-9
- Empirical Formula: C20H19F2N3O5
- Molecular Weight: 419.38
- Update Date: 2023-07-14 17:30:25
What is Dolutegravir Impurity 3?
The Uses of Dolutegravir Impurity 3
(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Properties of Dolutegravir Impurity 3
Melting point: | 95-100°C |
Boiling point: | 662.3±55.0 °C(Predicted) |
Density | 1.51±0.1 g/cm3(Predicted) |
storage temp. | -20°C Freezer, Under inert atmosphere |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 4.50±1.00(Predicted) |
color | Yellow |
Safety information for Dolutegravir Impurity 3
Computed Descriptors for Dolutegravir Impurity 3
New Products
Tubulysin M Tubulysin E (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin A 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-N-BOC-(S)-AMINO BUTYRONITRILE 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2,3-dichloro-6- nitrobenzonitrile (R)-Methanesulfonic acid 3-(3-fluoro-4- morpholin-4-yl- phenyl)-2-oxo- oxazolidin-5-ylmethyl Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
(4R,12aS)-N-(2,4-Difluorobenzyl)-7-Methoxy-4-Methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-[1,3]oxazino[3,2-d]pyrido[1,2-a]pyrazine-9-carboxaMide
Dolutegravir Impurity 6
GSK1349572 sodiuM salt
GSK1349572
Dolutegravir 2-Desfluoro Impurity
IMpurity of Dolutegravir
Dolutegravir 4-Desfluoro Impurity
Dolutegravir Impurity 5
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