dl-3-hydroxynorvaline
- CAS NO.：2280-42-4
- Empirical Formula: C5H11NO3
- Molecular Weight: 133.15
- MDL number: MFCD00010516
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-08-15 17:40:29
What is dl-3-hydroxynorvaline?
Definition
ChEBI: A non-proteinogenic amino-acid derivative that is norvaline (2-aminopentanoic acid) in which a hydrogen at position 3 is replaced by a hydroxy group.
Biochem/physiol Actions
3-Hydroxynorvaline (HNV) is a microbial, α amino acid threonine analogue which has antiviral activity (herpes virus) and is toxic to mammalian cells (embryotoxic and teratogenic) presumably via incorporation into proteins. 3-Hydroxynorvaline may be used as an unnatural amino acid to study the fidelity of protein translation at the level of acyl-tRNA editing. 3-Hydroxynorvaline may also be used to study enzymes and molecules involved in threonine metabolism.
Properties of dl-3-hydroxynorvaline
| Melting point: | 231.2℃ |
| Boiling point: | 328.4±32.0 °C(Predicted) |
| Density | 1.237±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| pka | 2.39±0.24(Predicted) |
| BRN | 1722350 |
Safety information for dl-3-hydroxynorvaline
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. |
Computed Descriptors for dl-3-hydroxynorvaline
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