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HomeProduct name listdl-3-hydroxynorvaline

dl-3-hydroxynorvaline

dl-3-hydroxynorvaline Structural

What is dl-3-hydroxynorvaline?

Definition

ChEBI: A non-proteinogenic amino-acid derivative that is norvaline (2-aminopentanoic acid) in which a hydrogen at position 3 is replaced by a hydroxy group.

Biochem/physiol Actions

3-Hydroxynorvaline (HNV) is a microbial, α amino acid threonine analogue which has antiviral activity (herpes virus) and is toxic to mammalian cells (embryotoxic and teratogenic) presumably via incorporation into proteins. 3-Hydroxynorvaline may be used as an unnatural amino acid to study the fidelity of protein translation at the level of acyl-tRNA editing. 3-Hydroxynorvaline may also be used to study enzymes and molecules involved in threonine metabolism.

Properties of dl-3-hydroxynorvaline

Melting point: 231.2℃
Boiling point: 328.4±32.0 °C(Predicted)
Density  1.237±0.06 g/cm3(Predicted)
storage temp.  -20°C
pka 2.39±0.24(Predicted)
BRN  1722350

Safety information for dl-3-hydroxynorvaline

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.

Computed Descriptors for dl-3-hydroxynorvaline

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