NIKKOMYCIN Z
- CAS NO.：59456-70-1
- Empirical Formula: C20H25N5O10
- Molecular Weight: 495.44
- MDL number: MFCD00869648
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:58
What is NIKKOMYCIN Z?
Description
Nucleoside-type antibiotic isolated from culture filtrates of Streptomyces tendae (19). Some analogs were also prepared by mutasynthesis, utilizing a uracil auxotroph of S. tendae.
The Uses of NIKKOMYCIN Z
Nikkomycins inhibit the growth of various plant pathogenic fungi but are inactive against bacteria and yeasts. Too susceptible to photodegradation by sunlight to be used in field application, and thus not developed commercially for agricultural use. Among the nikkomycins, nikkomycin Z is an orally active antifungal therapeutic agent for coccidioidomycosis. It is a competitive chitin synthase inhibitor that has been evaluated in mouse models for coccidioidomycosis.
Definition
ChEBI: A uridine-based nucleoside-peptide antibiotic which inhibits fungal chitin biosynthesis by inhibiting chitin synthase.
Pharmacology
By inhibiting chitin synthetase in fungi, nikkomycins inhibit cell wall synthesis, ultimately causing fungal cells to swell and burst.
Metabolism
There are no detailed reports on metabolism/transformation of nikkomycins in the environment.
Properties of NIKKOMYCIN Z
| Density | 1.646±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: soluble5mg/mL |
| pka | 2.70±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| Water Solubility | Water : ≥ 100 mg/mL (201.84 mM) |
Safety information for NIKKOMYCIN Z
Computed Descriptors for NIKKOMYCIN Z
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one N-octanoyl benzotriazole 3,4-Dibenzyloxybenzaldehyde 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) 4-HYDROXY BENZYL ALCOHOL 3-NITRO-2-METHYL ANILINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride tert-butyl 4- (ureidomethyl)benzylcarbamate diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
You may like
-
Nikkomycin Z from Streptomyces tendae ≥90% (HPLC) CAS 59456-70-1View Details
59456-70-1 -
Nikkomycin Z from Streptomyces tendae CAS 59456-70-1View Details
59456-70-1 -
N-Vinylformamide 99%View Details
13162-05-5 -
2-ETHYLPYRIDINE 100-71-0 99%View Details
100-71-0 -
7439-89-6 Electrolytic Iron Flakes 99.9% MaxView Details
7439-89-6 -
7439-89-6 98.0% MinView Details
7439-89-6 -
Reduced Iron Powder 99.8% MaxView Details
7439-89-6 -
Electrolytic Iron Powder 7439-89-6 99.8% MaxView Details
7439-89-6