Dipivefrin hydrochloride
Synonym(s):[2-(2,2-Dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate hydrochloride;Dipivefrine hydrochloride
- CAS NO.：64019-93-8
- Empirical Formula: C19H30ClNO5
- Molecular Weight: 387.8982
- MDL number: MFCD01697462
- EINECS: 264-609-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:09
What is Dipivefrin hydrochloride?
Description
Dipivefrin hydrochloride is an antiglaucoma prothrombotic drug that is hydrolyzed to its active compound epinephrine by esterases in the cornea.
Chemical properties
White or almost white, crystalline powder.
The Uses of Dipivefrin hydrochloride
Adrenergic (ophthalmic)
The Uses of Dipivefrin hydrochloride
Dipivefrine Hydrochloride acts as an anti-glaucoma agent.
Definition
ChEBI: The hydrochloride salt of dipivefrin. It is used topically as eye drops to reduce intra-ocular pressure in the treatment of open-angle glaucoma or ocular hypertension.
brand name
Akpro (Akorn); Propine (Allergan).
in vivo
Dipivefrin hydrochloride (0.3-10 μg/kg; i.p.;) induces enhancement of memory involves central beta- but not alpha-adrenergic mechanisms.
Properties of Dipivefrin hydrochloride
| Melting point: | 158-159° |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | Freely soluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent) and in methylene chloride. |
| form | neat |
| pka | 8.40(at 25℃) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C19H29NO5.ClH/c1-18(2,3)16(22)24-14-9-8-12(13(21)11-20-7)10-15(14)25-17(23)19(4,5)6;/h8-10,13,20-21H,11H2,1-7H3;1H |
Safety information for Dipivefrin hydrochloride
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for Dipivefrin hydrochloride
| InChIKey | VKFAUCPBMAGVRG-UHFFFAOYSA-N |
| SMILES | C1(OC(=O)C(C)(C)C)=CC(=CC=C1OC(=O)C(C)(C)C)C(O)CNC.Cl |
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