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HomeProduct name listDiphosgene

Diphosgene

Synonym(s):Diphosgene;di-Phosgene;TCF

  • CAS NO.:503-38-8
  • Empirical Formula: C2Cl4O2
  • Molecular Weight: 197.83
  • MDL number: MFCD00015553
  • EINECS: 207-965-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-15 10:43:33
Diphosgene Structural

What is Diphosgene?

Description

Diphosgene (DP), trichloromethyl chloroformate, is a clear, colorless liquid with an odor similar to phosgene. It is noncombustible, a strong irritant to the eyes and tissues, and is toxic by inhalation and ingestion. DP has a boiling point of 127°C–128°C (263°F) and a vapor pressure of 4.2 at 68°F (20°C). The liquid density is 1.65, which is heavier than water, and a melting/freezing point of 314°F (157°C). Inhalation LC50 is 3600 mg/m3 for 10 min. Effects of exposure are quite similar to phosgene gas. Its molecular formula is ClCOOCCl3, and the structure and molecular formula are shown in Figure 8.38. The DOT lists diphosgene as a 6.1 poison liquid. The NFPA 704 designation for CG is estimated to be health 4, flammability 0, reactivity 1, and special 0. It has a four-digit UN identification number of 2972.

Description

Diphosgene is a compound that acts chemically like two equivalents of phosgene. This is because upon reacting diphosgene forms one equivalent of phosgene (toxic gas). Diphosgene, being a liquid, is more convenient to handle than phosgene. Triphosgene, which is a solid, is a related compound that chemically acts like three equivalents of phosgene.

Chemical properties

clear colorless liquid

The Uses of Diphosgene

In organic synthesis; as war gas.

The Uses of Diphosgene

Trichloromethyl chloroformate is used as a reagent in the synthesis of organic compounds. It serves as a source of phosgene used in some laboratory preparations. Also, it is used as a reactant for the synthesis of cyclic carbamimidates, N-alkenyl and cycloalkyl carbamates and prostate-specific membrane antigen-targeted anticancer prodrugs. In addition, it is involved in the preparation of an erythromycin A derivatives and antibody-drug conjugates. It is utilized in the conversion of amines, carboxylic acids, formamides in to isocyanates, acid chlorides and isocyanides respectively.

The Uses of Diphosgene

Reactant for preparation of:

  • Cyclic carbamimidates using a monophosphine gold(i) catalyst
  • N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands
  • Prostate-specific membrane antigen-targeted anticancer prodrugs
  • Potential west nile virus protease inhibitors
  • Antibody-drug conjugates (ADCs)
  • Erythromycin A derivatives

Definition

diphosgene: A colourless liquid,ClCO.O.CCl3, originally used in 1916by Germany in World War I as achemical warfare agent. It is nowused as a reagent in organic synthesis.See also carbonyl chloride.

General Description

Colorless liquid, odorless to fruity.

Air & Water Reactions

Decomposes slowly in water or moist air (or when inhaled) to form very corrosive hydrogen chloride gas (hydrochloric acid) and carbon monoxide.

Hazard

Toxic by inhalation and ingestion, strong irritant to tissue.

Fire Hazard

Some may burn but none ignite readily. Vapors from liquefied gas are initially heavier than air and spread along ground. Some of these materials may react violently with water. Cylinders exposed to fire may vent and release toxic and/or corrosive gas through pressure relief devices. Containers may explode when heated. Ruptured cylinders may rocket.

Safety Profile

Low toxicity by inhalation. A corrosive liquid. When heated to decomposition it emits toxic vapors of Cl-.

Properties of Diphosgene

Melting point: -57 °C
Boiling point: 20 °C10 mm Hg(lit.)
Density  1.64
refractive index  n20/D 1.458
Flash point: >110°C
storage temp.  2-8°C
solubility  Chloroform (Soluble), Ethyl Acetate (Sparingly)
form  Liquid
appearance Liquid
color  Clear colorless
Water Solubility  may decompose
Sensitive  Moisture Sensitive
Merck  14,3334
BRN  970225
Stability: Hygroscopic, Moisture Sensitive
CAS DataBase Reference 503-38-8(CAS DataBase Reference)
NIST Chemistry Reference Trichloromethyl chloroformate(503-38-8)
EPA Substance Registry System Carbonochloridic acid, trichloromethyl ester (503-38-8)

Safety information for Diphosgene

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H302:Acute toxicity,oral
H314:Skin corrosion/irritation
H330:Acute toxicity,inhalation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Diphosgene

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