Allyl chloroformate

Chemical properties

Colorless liquid

The Uses of Allyl chloroformate

Allyl Chloroformate is used in the synthesis of poly(ethylene oxide) hybrid systems for therapeutic applications and drug delivery. Also used in the synthesis of benzothiazole derivatives with potent anti-tumor properties.

General Description

A colorless liquid with a pungent odor. Flash point 88°F. Corrosive to metals and tissue. Very toxic by inhalation, ingestion and/or skin contact. Vapors are heavier than air.

Air & Water Reactions

Highly flammable. Water reaction produces heat and acidic HCl. In the presence of moist air, corrosive hydrogen chloride is produced.

Reactivity Profile

Acid halides, such as Allyl chloroformate, are water reactive; some are violently reactive. They are incompatible with strong oxidizing agents, alcohols, amines, alkali. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

Vapor irritates eyes and respiratory tract. Contact with liquid causes eye and skin irritation, and ingestion irritates mouth and stomach.

Chemical Reactivity

Reactivity with Water Reacts slowly generating hydrogen chloride; Reactivity with Common Materials: Corrosive metals; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Flush with water, rinse with sodium bicarbonate solution; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Poison by inhalation and ingestion. Corrosive. Dangerous when exposed to heat, open flame (or sparks), or powerful oxidizers. Can react with oxidizing materials. To fight fire, use alcohol foam, spray or mist, dry chemical. When heated to decomposition it emits toxic fumes of Cl-. See also ALLYL COMPOUNDS and ESTERS.