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HomeProduct name listDimethyl 2-oxoglutarate

Dimethyl 2-oxoglutarate

Synonym(s):Dimethyl α-ketoglutarate

Dimethyl 2-oxoglutarate Structural

What is Dimethyl 2-oxoglutarate?

Chemical properties

Slight Yellow Liquid

The Uses of Dimethyl 2-oxoglutarate

Dimethyl 2-oxoglutarate may be used to synthesize the conformationally constrained PNA (peptide nucleic acid) -monomer capable of binding thymine in a triplex motif. It may be used in the synthesis of 4-aryl kainic acid analogs, via highly stereoselective Michael addition reaction with nitrostyrene.

Definition

ChEBI: Dimethyl 2-oxoglutarate is an oxo carboxylic acid.

General Description

Dimethyl 2-oxoglutarate is a key intermediate formed during the Krebs cycle and an important nitrogen transporter in the biological metabolic pathways. The electrochemical behavior of dimethyl-2-oxoglutarate has been investigated by cyclic voltammetry, square wave voltammetry and differential pulse voltammetry using a glassy carbon electrode.

Properties of Dimethyl 2-oxoglutarate

Boiling point: 90-95 °C0.4 mm Hg(lit.)
Density  1.203 g/mL at 25 °C(lit.)
refractive index  n20/D 1.439(lit.)
Flash point: >230 °F
storage temp.  -20°C
solubility  DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
form  clear liquid
color  Colorless to Light yellow to Light orange
CAS DataBase Reference 13192-04-6(CAS DataBase Reference)

Safety information for Dimethyl 2-oxoglutarate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Dimethyl 2-oxoglutarate

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