Dihydrostreptomycin sulfate
Synonym(s):Dihydrostreptomycin sesquisulfate
- CAS NO.:5490-27-7
- Empirical Formula: C21H43N7O16S
- Molecular Weight: 681.67
- MDL number: MFCD00167162
- EINECS: 226-823-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-24 17:21:45
What is Dihydrostreptomycin sulfate?
Chemical properties
White Solid
Originator
Dihydrostrepto,MSD ,US,1948
The Uses of Dihydrostreptomycin sulfate
As a derivative of Streptomycin (S687500) with antimicrobial activity, Dihydrostreptomycin sulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.
The Uses of Dihydrostreptomycin sulfate
antibacterial, tuberculostatic
The Uses of Dihydrostreptomycin sulfate
Dihydrostreptomycin sesquisulfate is used in veterinary medicine to treat bovine infection and also as an effective antibiotic to control pests found in crops.. Other studies have also used it as an electrode for a cochlear amplifier in the hair-cell bundle of lizards.
What are the applications of Application
Dihydrostreptomycin sesquisulfate is an inhibitor of protein synthesis
Manufacturing Process
Dihydrostreptomycin sulfate may be prepared from streptomycin sulfate by catalytic hydrogenation (Merck, Pfizer, Cyanamid), electrolytic reduction (Schenley, Olin Mathieson), or by sodium borohydride reduction (Bristol), or by isolation from a fermentation process (Takeda).
Therapeutic Function
Antibiotic
Purification Methods
It crystallises from H2O, MeOH, n-BuOH or methyl ethyl ketone. The crystals are not hygroscopic like the amorphous powder; however, both forms are soluble in H2O but the amorphous solid is about 10 times more soluble than the crystals. The free base also crystallises from H2O/Me2CO and has [] D -92o (aqueous solution pH 7.0). [Solomons & Regina Science 109 515 1949, Wolf et al. Science 109 515 1949, McGilveray & Rinehart J Am Chem Soc 87 4003 1956]. [Beilstein 18 III/IV 7538.]
Properties of Dihydrostreptomycin sulfate
alpha | D25 -88.5° (1% soln) |
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: 50 mg/mL, clear, faintly yellow |
form | crystalline |
color | white to light yellow |
Water Solubility | Soluble in water |
Merck | 13,3201 |
BRN | 3894221 |
Stability: | Hygroscopic |
EPA Substance Registry System | D-Streptamine, O-2-deoxy-2-(methylamino)-.alpha.-L-glucopyranosyl-(1.fwdarw.2)-O-5-deoxy-3-C-(hydroxymethyl)-.alpha.-L-lyxofuranosyl-(1.fwdarw.4)-N,N'-bis(aminoiminomethyl)-, sulfate (2:3) (salt) (5490-27-7) |
Safety information for Dihydrostreptomycin sulfate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P202:Do not handle until all safety precautions have been read and understood. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P308+P313:IF exposed or concerned: Get medical advice/attention. |
Computed Descriptors for Dihydrostreptomycin sulfate
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