DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
Synonym(s):2,2′-Oxydiethyl ditosylate;Bis(2-tosyloxyethyl)ether;Diethylene glycol ditosylate
- CAS NO.:7460-82-4
- Empirical Formula: C18H22O7S2
- Molecular Weight: 414.49
- MDL number: MFCD00026001
- EINECS: 628-596-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-27 16:40:14
What is DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)?
Description
Tos-PEG3-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Chemical properties
White to off-white powder
The Uses of DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
Diethylene glycol di(p-toluenesulfonate) was used in the synthesis of bis(dibenzosulfoxo)-27,30,35,38-tetramethyl-24-crown-6, bis(dibenzosulfoxo)-21,24,29,32-tetramethyl-18-crown-4, dibenzosulfoxo-15,18-dimethyl-12-crown-3 and dibenzosulfoxo-12,15-dimethyl-9-crown-2 macrocycles.
Purification Methods
Purify the ester by recrystallisation from Me2CO and dry it in a vacuum. [Beilstein 11 III 225.]
Properties of DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
Melting point: | 87-89 °C (lit.) |
Boiling point: | 581.2±45.0 °C(Predicted) |
Density | 1.301±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
color | Off-White |
BRN | 583800 |
CAS DataBase Reference | 7460-82-4(CAS DataBase Reference) |
EPA Substance Registry System | Ethanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate) (7460-82-4) |
Safety information for DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
InChIKey | VYVPNTJBGPQTFA-UHFFFAOYSA-N |
New Products
Tubulysin D Tubulysin B Tubulysin G (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 1-(1,1-Difluoroethyl)-2-fluorobenzene 4-(Benzyloxy)-3-bromophenylacetic Acid 2,2-Difluoropropanol Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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2,3-O-ISOPROPYLIDENE-1,6-DITOSYL-L-SORBOSE
2,3-O-Isopropylidene-1,6-ditosyl-L-sorbose
DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
METHYL-5-O-ACETYL-2,3-DI-O-TOLUOLSULFONYL-BETA-D-RIBOFURANOSIDE
1,6-ANHYDRO-2,4-DI-O-P-TOLUENESULFONYL-BETA-D-GLUCOPYRANOSE
AURORA KA-659
1-O-ACETYL-5-O-BENZOYL-2,3-DI-O-TOLUOLSULFONYL-D-RIBOFURANOSE
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