DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)

Synonym(s):2,2′-Oxydiethyl ditosylate;Bis(2-tosyloxyethyl)ether;Diethylene glycol ditosylate

CAS NO.：7460-82-4
Empirical Formula: C18H22O7S2
Molecular Weight: 414.49
MDL number: MFCD00026001
EINECS: 628-596-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-25 23:13:37

DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE) Structural

What is DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)?

Description

Tos-PEG3-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Chemical properties

White to off-white powder

The Uses of DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)

Diethylene glycol di(p-toluenesulfonate) was used in the synthesis of bis(dibenzosulfoxo)-27,30,35,38-tetramethyl-24-crown-6, bis(dibenzosulfoxo)-21,24,29,32-tetramethyl-18-crown-4, dibenzosulfoxo-15,18-dimethyl-12-crown-3 and dibenzosulfoxo-12,15-dimethyl-9-crown-2 macrocycles.

Purification Methods

Purify the ester by recrystallisation from Me2CO and dry it in a vacuum. [Beilstein 11 III 225.]

Properties of DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)

Melting point:	87-89 °C (lit.)
Boiling point:	581.2±45.0 °C(Predicted)
Density	1.301±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
form	Solid
color	Off-White
BRN	583800
CAS DataBase Reference	7460-82-4(CAS DataBase Reference)
EPA Substance Registry System	Ethanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate) (7460-82-4)

Safety information for DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.