DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
Synonym(s):2,2′-Oxydiethyl ditosylate;Bis(2-tosyloxyethyl)ether;Diethylene glycol ditosylate
- CAS NO.：7460-82-4
- Empirical Formula: C18H22O7S2
- Molecular Weight: 414.49
- MDL number: MFCD00026001
- EINECS: 628-596-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:08:52
What is DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)?
Description
Tos-PEG3-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
Chemical properties
White to off-white powder
The Uses of DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
Diethylene glycol di(p-toluenesulfonate) was used in the synthesis of bis(dibenzosulfoxo)-27,30,35,38-tetramethyl-24-crown-6, bis(dibenzosulfoxo)-21,24,29,32-tetramethyl-18-crown-4, dibenzosulfoxo-15,18-dimethyl-12-crown-3 and dibenzosulfoxo-12,15-dimethyl-9-crown-2 macrocycles.
Purification Methods
Purify the ester by recrystallisation from Me2CO and dry it in a vacuum. [Beilstein 11 III 225.]
Properties of DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
| Melting point: | 87-89 °C (lit.) |
| Boiling point: | 581.2±45.0 °C(Predicted) |
| Density | 1.301±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| color | Off-White |
| BRN | 583800 |
| CAS DataBase Reference | 7460-82-4(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanol, 2,2'-oxybis-, bis(4-methylbenzenesulfonate) (7460-82-4) |
Safety information for DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE)
| InChIKey | VYVPNTJBGPQTFA-UHFFFAOYSA-N |
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