Diethyl bromodifluoromethanephosphonate
Synonym(s):(Bromodifluoromethyl)phosphonic acid diethyl ester
- CAS NO.:65094-22-6
- Empirical Formula: C5H10BrF2O3P
- Molecular Weight: 267.01
- MDL number: MFCD00069118
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-15 18:41:30
What is Diethyl bromodifluoromethanephosphonate?
The Uses of Diethyl bromodifluoromethanephosphonate
Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis.
The Uses of Diethyl bromodifluoromethanephosphonate
Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 3437, 1984 DOI: 10.1021/jo00192a056
Properties of Diethyl bromodifluoromethanephosphonate
Boiling point: | 40-41 °C/0.05 mmHg (lit.) |
Density | 1.503 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
solubility | Chloroform, Ethyl Acetate |
form | liquid |
color | colorless |
Specific Gravity | 1.503 |
Water Solubility | Not miscible or difficult to mix in water. |
BRN | 1944045 |
CAS DataBase Reference | 65094-22-6(CAS DataBase Reference) |
Safety information for Diethyl bromodifluoromethanephosphonate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P321:Specific treatment (see … on this label). P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Diethyl bromodifluoromethanephosphonate
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin G Tubulysin H Tubulysin I Tubulysin F Potassium HMDS (1.0 M in THF) 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Fuel shell 3-Morpholino-1-[4-(2-oxo-1-piperidyl)phenyl]-5,6-dihydropyridin-2(1H)-one Methyl 4-amino-3-(pyrrolidin-1-yl)benzoate 3,3,6,6-Tetramethylcyclohexane-1,2-dione Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 4-(Azidomethyl)-3-chloropyridine 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (2S,4R)-4-((tert-butoxycarbonyl)amino)-5-(4-hydroxyphenyl)-2-methylpentanoic acid 2,2-dibromopropanoateRelated products of tetrahydrofuran
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