Diethyl bromodifluoromethanephosphonate
Synonym(s):(Bromodifluoromethyl)phosphonic acid diethyl ester
- CAS NO.：65094-22-6
- Empirical Formula: C5H10BrF2O3P
- Molecular Weight: 267.01
- MDL number: MFCD00069118
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-15 18:41:30
What is Diethyl bromodifluoromethanephosphonate?
The Uses of Diethyl bromodifluoromethanephosphonate
Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis.
The Uses of Diethyl bromodifluoromethanephosphonate
Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 3437, 1984 DOI: 10.1021/jo00192a056
Properties of Diethyl bromodifluoromethanephosphonate
| Boiling point: | 40-41 °C/0.05 mmHg (lit.) |
| Density | 1.503 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | liquid |
| color | colorless |
| Specific Gravity | 1.503 |
| Water Solubility | Not miscible or difficult to mix in water. |
| BRN | 1944045 |
| CAS DataBase Reference | 65094-22-6(CAS DataBase Reference) |
Safety information for Diethyl bromodifluoromethanephosphonate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P321:Specific treatment (see … on this label). P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Diethyl bromodifluoromethanephosphonate
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