Diethyl bromodifluoromethanephosphonate
Synonym(s):(Bromodifluoromethyl)phosphonic acid diethyl ester
- CAS NO.：65094-22-6
- Empirical Formula: C5H10BrF2O3P
- Molecular Weight: 267.01
- MDL number: MFCD00069118
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-15 18:41:30
What is Diethyl bromodifluoromethanephosphonate?
The Uses of Diethyl bromodifluoromethanephosphonate
Efficient difluoroalkylation of aryl boronic acids via palladium catalysis. Novel, moisture-stable bromodifluoromethylated phosphonate, ester, and amide. Efficient coupling with aryl boronic acids via Pd catalysis.
The Uses of Diethyl bromodifluoromethanephosphonate
Diethyl (bromodifluoromethyl)phosphonate is used as a reactant for the preparation of phosphopeptide mimetic prodrugs targeted to Src homology 2 (SH2) domain of signal transducer and activator of transcription 3 (Stat3), synthesis of Mycobacterium tuberculosis protein tyrosine phosphatase inhibitory difluoromethylphosphonic acid derivatives via multi step synthesis with Suzuki coupling and resolution as key steps and P-C bond cleavage on basic hydrolysis.
Synthesis Reference(s)
The Journal of Organic Chemistry, 49, p. 3437, 1984 DOI: 10.1021/jo00192a056
Properties of Diethyl bromodifluoromethanephosphonate
| Boiling point: | 40-41 °C/0.05 mmHg (lit.) |
| Density | 1.503 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | >230 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | liquid |
| color | colorless |
| Specific Gravity | 1.503 |
| Water Solubility | Not miscible or difficult to mix in water. |
| BRN | 1944045 |
| CAS DataBase Reference | 65094-22-6(CAS DataBase Reference) |
Safety information for Diethyl bromodifluoromethanephosphonate
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P321:Specific treatment (see … on this label). P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for Diethyl bromodifluoromethanephosphonate
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
Diethyl (Bromodifluoromethyl)phosphonate CAS 65094-22-6View Details
65094-22-6 -
Diethyl bromodifluoromethanephosphonate 98% (GC) CAS 65094-22-6View Details
65094-22-6 -
Bromodifluoromethyl diethylphosphonate 95% CAS 65094-22-6View Details
65094-22-6 -
Diethyl (bromodifluoromethyl)phosphonate CAS 65094-22-6View Details
65094-22-6 -
Diethyl (bromodifluoromethyl)phosphonate, 97% CAS 65094-22-6View Details
65094-22-6 -
Diethyl (bromodifluoromethyl)phosphonate CAS 65094-22-6View Details
65094-22-6 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
Lithium ClavulanateView Details
61177-44-4
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.