diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate

CAS NO.：120533-76-8
Empirical Formula: C24H25NO4
Molecular Weight: 391.46
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-18 11:31:20

What is diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate?

Description

BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable.

The Uses of diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate

Diethyl 1-Benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a cell-permeable and potent SIRT activator that induces cell cycle arrest. SIRT modulators have therapeutic potential the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases.

Definition

ChEBI: 4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester is a dihydropyridine.

References

1) Mai et al. (2009), Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors; J. Med.Chem.,52 5496

Properties of diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate

Melting point:	139-141 °C(Solv: cyclohexane (110-82-7); benzene (71-43-2))
Boiling point:	525.5±50.0 °C(Predicted)
Density	1.183±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in DMSO (up to 5 mg/ml).
form	solid
pka	2.05±0.70(Predicted)
color	Off-white
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety information for diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.