2-N-HEXYL-4-PENTYNOIC ACID

CAS NO.：96017-59-3
Empirical Formula: C11H18O2
Molecular Weight: 182.26
MDL number: MFCD00946863
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 15:53:33

What is 2-N-HEXYL-4-PENTYNOIC ACID?

Description

2-hexyl-4-Pentynoic acid is a derivative of valproic acid , an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC₅₀ = 13 μM) than valproic acid (IC₅₀ = 398 μM). 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 μM. It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 μM.

References

1) Eikel et al. (2006), Teratogenic effects mediated by inhibition of histone deacetylases: evidence from quantitative structure activity relationships of 20 valproic acid derivatives; Chem. Res. Toxicol., 19 272 2) Leng et al. (2010), Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction; Neurosci. Lett., 476 127

Properties of 2-N-HEXYL-4-PENTYNOIC ACID

Boiling point:	287.1±23.0 °C(Predicted)
Density	0.94
refractive index	1.4450-1.4510
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
form	oil
pka	4.24±0.21(Predicted)
color	Colorless
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months

Safety information for 2-N-HEXYL-4-PENTYNOIC ACID

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection.