dichlorisone
- CAS NO.:7008-26-6
- Empirical Formula: C21H26Cl2O4
- Molecular Weight: 413.34
- MDL number: MFCD00232919
- EINECS: 2302838
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:56
What is dichlorisone ?
Originator
Diloderm ,Schering,US,1960
The Uses of dichlorisone
Dichlorisone is a 9α,11β-dichloro corticoid. Dichlorisone has anti-antiinflammatory potency. Dichlorisone could be modifed to be used as glucocorticoid receptor agonists as well as a P-glycoprotein inhibitor.
Manufacturing Process
A solution of 1.0 g of 1,4,9(11)-pregnatriene-17α,21-diol-3,20-dione-21-
acetate and 5.0 g of lithium chloride in 40 ml of glacial acetic acid is treated
with 0.410 g of N-chlorosuccinimide, followed by 0.104 g of anhydrous
hydrogen chloride dissolved in 2.5 ml of tetrahydrofuran. The reaction mixture
is stirred for 2 hours and poured into ice water. The crude product is filtered
and washed with water to give 1.12 g of solid material, which is recrystallized
from acetone-hexane to give substantially pure 9α,11β-dichloro-1,4-
pregnadiene-17α,21-diol-3,20-dione-21-acetate; MP 246°C to 253°C (dec.).
Therapeutic Function
Antipruritic, Antihistaminic, Appetite stimulant
Properties of dichlorisone
Melting point: | 238-241 °C (decomp)(Solv: acetone (67-64-1)) |
alpha | D20 +134° (pyridine) |
Boiling point: | 586.4±50.0 °C(Predicted) |
Density | 1.37±0.1 g/cm3(Predicted) |
solubility | Chloroform (Slightly, Heated), DMSO (Slightly, Heated), Pyridine (Slightly, Sonicated) |
form | Solid |
pka | 11.99±0.70(Predicted) |
color | White to Off-White |
Safety information for dichlorisone
Computed Descriptors for dichlorisone
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