Di-tert-butyl N,N-diethylphosphoramidite
- CAS NO.：117924-33-1
- Empirical Formula: C12H28NO2P
- Molecular Weight: 249.33
- MDL number: MFCD00134307
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is Di-tert-butyl N,N-diethylphosphoramidite?
Chemical properties
Clear Colourless Liquid
The Uses of Di-tert-butyl N,N-diethylphosphoramidite
Di-tert-butyl N,N-diethylphosphoramidite is a useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters.
The Uses of Di-tert-butyl N,N-diethylphosphoramidite
A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.
Properties of Di-tert-butyl N,N-diethylphosphoramidite
| Boiling point: | 39-41 °C/0.3 mmHg (lit.) |
| Density | 0.896 g/mL at 25 °C (lit.) |
| refractive index | n |
| Flash point: | 173 °F |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Oil |
| pka | 4.41±0.70(Predicted) |
| color | Clear Colourless |
| Water Solubility | Hydrolyzes in water. Soluble in chloroform and methanol. |
| Sensitive | Moisture Sensitive |
| BRN | 4175262 |
| Stability: | Moisture Sensitive |
| CAS DataBase Reference | 117924-33-1(CAS DataBase Reference) |
Safety information for Di-tert-butyl N,N-diethylphosphoramidite
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Di-tert-butyl N,N-diethylphosphoramidite
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