DESMETHYL LOPERAMIDE
- CAS NO.:66164-07-6
- Empirical Formula: C28H31ClN2O2
- Molecular Weight: 463.01
- MDL number: MFCD08063667
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is DESMETHYL LOPERAMIDE?
Chemical properties
Off-White Solid
The Uses of DESMETHYL LOPERAMIDE
A metabolite of Loperamide; a new and improved PET radiotracer for imaging P-gp function
The Uses of DESMETHYL LOPERAMIDE
Loperamide is an opiate which potently and selectively activates μ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. N-Desmethyl-loperamide (dLop) is a major metabolite of loperamide. Like loperamide, dLop is a substrate of the ATP-dependent efflux transporter, P-glycoprotein. As a result, both the parent compound and the metabolite display restricted passage through the blood-brain barrier. dLop in biological samples can be analyzed by a variety of methods.
What are the applications of Application
N-Desmethyl Loperamide is a metabolite of Loperamide
Definition
ChEBI: A monocarboxylic acid amide that is the methylamide of 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylbutanoic acid.
Properties of DESMETHYL LOPERAMIDE
Melting point: | 219-221?C |
Boiling point: | 678.3±55.0 °C(Predicted) |
Density | 1?+-.0.06 g/cm3(Predicted) |
storage temp. | -20°C Freezer |
solubility | DMF: 2 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 1 mg/ml |
form | A crystalline solid |
pka | 13.85±0.20(Predicted) |
Safety information for DESMETHYL LOPERAMIDE
Computed Descriptors for DESMETHYL LOPERAMIDE
New Products
Tert-butyl bis(2-chloroethyl)carbamate (S)-3-Aminobutanenitrile hydrochloride N-Boc-D-alaninol N-BOC-D/L-ALANINOL N-octanoyl benzotriazole 4-Hydrazinobenzoic acid 3,4-Dibenzyloxybenzaldehyde 1,1’-CARBONYLDIIMIDAZOLE R-2-BENZYLOXY PROPIONIC ACID 1,1’-CARBONYLDI (1,2-4 TRIAZOLE) 4-HYDROXY BENZYL ALCOHOL 3-NITRO-2-METHYL ANILINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 5-BROMO-2CYANO PYRIDINE 5,6-Dimethoxyindanone 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 4-methoxy-3,5-dinitropyridine 2-(Cyanocyclohexyl)acetic acid 2-aminopropyl benzoate hydrochloride 1-(4-(aminomethyl)benzyl)urea hydrochloride tert-butyl 4- (ureidomethyl)benzylcarbamate diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
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